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1. WO2005091750 - METHOD AND MATERIALS FOR USE IN DIAGNOSING VIRAL MYOCARDITIS

Publication Number WO/2005/091750
Publication Date 06.10.2005
International Application No. PCT/US2005/010078
International Filing Date 24.03.2005
IPC
A61K 49/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
CPC
A61K 49/0002
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
0002General or multifunctional contrast agents, e.g. chelated agents
A61P 31/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
Applicants
  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US]/[US] (AllExceptUS)
  • KNOWLTON, Kirk [US]/[US] (UsOnly)
  • TSIMIKAS, Sotirios [US]/[US] (UsOnly)
Inventors
  • KNOWLTON, Kirk
  • TSIMIKAS, Sotirios
Agents
  • TAYLOR, Stacy, L.
Priority Data
60/556,15424.03.2004US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHOD AND MATERIALS FOR USE IN DIAGNOSING VIRAL MYOCARDITIS
(FR) METHODE ET PRODUITS UTILISES POUR DIAGNOSTIQUER UNE MYOCARDITE VIRALE
Abstract
(EN)
The invention consists of assay methods, assay kits and antibodies for detecting the polypeptide fragments of dystrophin protein cleavage by enteroviral protease 2A as a result of an enteroviral infection in the heart. The presence of dystrophin cleavage products in the myocytes or blood of a subject is diagnostic for enteroviral infection and myocarditis resulting therefrom.
(FR)
Cette invention concerne des méthodes de dosage, des trousses de dosage ainsi que des anticorps permettant de détecter les fragments polypeptidiques du clivage de la protéine dystrophine par la protéase entérovirale 2A résultant d'une infection entérovirale dans le coeur. La présence de produits du clivage de la dystrophine dans les myocytes ou dans le sang d'un sujet révèle la présence d'une infection entérovirale et de la myocardite qui en résulte.
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