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1. WO2005077417 - INHIBITION OF FACTOR B, THE ALTERNATIVE COMPLEMENT PATHWAY AND METHODS RELATED THERETO

Publication Number WO/2005/077417
Publication Date 25.08.2005
International Application No. PCT/US2005/004346
International Filing Date 10.02.2005
IPC
A61K 39/395 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C12P 21/08 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21Preparation of peptides or proteins
08Monoclonal antibodies
CPC
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
C07K 16/40
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
40against enzymes
C07K 2317/76
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
70characterized by effect upon binding to a cell or to an antigen
76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Applicants
  • THE REGENTS OF THE UNIVERSITY OF COLORADO [US]/[US] (AllExceptUS)
  • NATIONAL JEWISH MEDICAL AND RESEARCH CENTER [US]/[US] (AllExceptUS)
  • MUSC FOUNDATION FOR RESEARCH DEVELOPMENT [US]/[US] (AllExceptUS)
  • HOLERS, Vernon, Michael [US]/[US] (UsOnly)
  • THURMAN, Joshua, M. [US]/[US] (UsOnly)
  • TAUBE, Christian [DE]/[US] (UsOnly)
  • GELFAND, Erwin, W. [US]/[US] (UsOnly)
  • GILKESON, Gary, Steven [US]/[US] (UsOnly)
Inventors
  • HOLERS, Vernon, Michael
  • THURMAN, Joshua, M.
  • TAUBE, Christian
  • GELFAND, Erwin, W.
  • GILKESON, Gary, Steven
Agents
  • SEBOR, Angela, Dallas
Priority Data
60/543,59410.02.2004US
60/636,23914.12.2004US
PCT/US2004/01504013.05.2004US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) INHIBITION OF FACTOR B, THE ALTERNATIVE COMPLEMENT PATHWAY AND METHODS RELATED THERETO
(FR) INHIBITION DU FACTEUR B ET DE LA VOIE DU COMPLEMENT ALTERNATIVE ET PROCEDES ASSOCIES
Abstract
(EN) Disclosed are novel inhibitors of the alternative complement pathway and particularly, novel anti-factor B antibodies. Also disclosed is the use of such inhibitors to reduce or prevent airway hyperresponsiveness and/or airway inflammation by selectively inhibiting the alternative complement pathway, thereby treating diseases in which such conditions play a role. Also disclosed is the use of such inhibitors to reduce or prevent other diseases and conditions, including ischemia-reperfusion injury, by inhibition of the alternative complement pathway.
(FR) L'invention concerne de nouveaux inhibiteurs de la voie du complément alternative, en particulier de nouveaux anticorps anti-facteur B. L'invention concerne également l'utilisation de ces inhibiteurs dans l'atténuation ou la prévention de l'hypersensibilité des voies aériennes et/ou des inflammations des voies aériennes, par l'inhibition sélective de la voie du complément alternative, ce qui permet de traiter les maladies dans lesquelles ces états jouent un rôle. L'invention concerne également l'utilisation de ces inhibiteurs dans l'atténuation ou la prévention d'autres maladies ou états, notamment les lésions d'ischémie-reperfusion, par l'inhibition de la voie du complément alternative.
Related patent documents
BRPI0506629This application is not viewable in PATENTSCOPE because the national phase entry has not been published yet or the national entry is issued from a country that does not share data with WIPO or there is a formatting issue or an unavailability of the application.
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