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Pub. No.:    WO/2005/069192    International Application No.:    PCT/US2005/001338
Publication Date: 28.07.2005 International Filing Date: 13.01.2005
C12N 9/40 (2006.01)
Applicants: TRANSKARYOTIC THERAPIES, INC. [US/US]; 700 Main Street, Cambridge, MA 02139 (US) (For All Designated States Except US).
NIH/NIAID [US/US]; 6610 Rockledge Drive, Bethesda, MD 20892-6612 (US) (For All Designated States Except US).
GARMAN, Scott, C. [US/US]; (US).
GARBOCZI, David, N. [US/US]; (US).
TRECO, Douglas, A. [US/US]; (US).
SELDEN, Richard, F. [US/US]; (US).
BOROWSKI, Marianne [US/US]; (US).
KINOSHITA, Carol, M. [US/US]; (US)
Inventors: GARMAN, Scott, C.; (US).
GARBOCZI, David, N.; (US).
TRECO, Douglas, A.; (US).
SELDEN, Richard, F.; (US).
BOROWSKI, Marianne; (US).
KINOSHITA, Carol, M.; (US)
TRANSKARYOTIC THERAPIES, INC.; 700 Main Street, Cambridge, MA 02139 (US)
Priority Data:
60/536,451 13.01.2004 US
Abstract: front page image
(EN)This invention pertains to the X-ray crystal structure of the human &agr;-galactosidase glycoprotein. More specifically, the invention relates to crystallized compositions of human &agr;-galactosidase and to crystallized complexes of human oc-galactosidase and its catalytic product &agr;-galactose. The invention further relates to a computer programmed with the structure coordinates of the human a galactosidase's active site wherein said computer is capable of displaying a three-dimensional representation of that active site. The invention also relates to methods for rational drug design based on the structural data for human &agr;-galactosidase provided on computer readable media, as analyzed on a computer system having suitable computer algorithms.
(FR)L'invention concerne la structure cristalline radiographique de la glycoprotéine $g(a)-galactosidase humaine. Plus spécifiquement, l'invention concerne des compositions cristallisées d'$g(a)-galactosidase humaine et des complexes cristallisés d'$g(a)-galactosidase humaine et de son produit catalytique, $g(a)-galactose. L'invention concerne en outre un ordinateur programmé avec les coordonnées de la structure du site actif de l'$g(a)-galactosidase humaine, l'ordinateur étant capable d'afficher une représentation tridimensionnelle de ce site actif. L'invention concerne également des méthodes de conception rationnelle de médicaments sur la base des données structurelles de l'$g(a)-galactosidase humaine disponibles sur des supports lisibles par ordinateur et analysées par un système informatique pourvu d'algorithmes informatiques appropriés.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)