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1. (WO2005069010) DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH HUMAN METABOTROPIC GLUTAMATE RECEPTOR 4 (MGLUR4)
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2005/069010 International Application No.: PCT/EP2005/000074
Publication Date: 28.07.2005 International Filing Date: 07.01.2005
IPC:
C07K 14/705 (2006.01) ,G01N 33/68 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
Applicants: GOLZ, Stefan[DE/DE]; DE (UsOnly)
BRÜGGEMEIER, Ulf[DE/DE]; DE (UsOnly)
GEERTS, Andreas[DE/DE]; DE (UsOnly)
SUMMER, Holger[DE/DE]; DE (UsOnly)
BAYER HEALTHCARE AG[DE/DE]; 51368 Leverkusen, DE (AllExceptUS)
Inventors: GOLZ, Stefan; DE
BRÜGGEMEIER, Ulf; DE
GEERTS, Andreas; DE
SUMMER, Holger; DE
Common
Representative:
BAYER HEALTHCARE AG; Law and Patents Patents and Licensing 51368 Leverkusen, DE
Priority Data:
04000961.519.01.2004EP
Title (EN) DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH HUMAN METABOTROPIC GLUTAMATE RECEPTOR 4 (MGLUR4)
(FR) DIAGNOSTICS ET TRAITEMENTS DE PATHOLOGIQUES ASSOCIEES AU RECEPTEUR METABOTROPIQUE DU GLUTAMATE 4 (MGLUR4) HUMAIN
Abstract:
(EN) The invention provides a human mGluR4 which is associated with the neurological diseases, urological diseases, respiratory diseases, cancer, reproduction disorders and cardiovascular diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of neurological diseases, urological diseases, respiratory diseases, cancer, reproduction disorders and cardiovascular diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of mGluR4 as well as pharmaceutical compositions comprising such compounds.
(FR) L'invention concerne un récepteur mGluR4 humain qui est associé aux pathologies neurologiques, urologiques, respiratoires, au cancer, aux troubles de fonction reproductrice, et aux maladies cardiovasculaires. L'invention concerne également des épreuves permettant l'identification de composés pouvant servir au traitement ou à la prévention de pathologiques neurologique, urologiques, respiratoires, des cancers, des troubles de la fonction reproductrice, et des maladies cardiovasculaires. L'invention concerne en outre des composés qui se lient au récepteur mGluR4 ou inhibent son activité, ainsi que des compositions pharmaceutiques contenant de tels composés.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)