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Machine translation
1. (WO2005069000) METHODS OF IDENTIFYING CYTOTOXIC EFFECTS IN QUIESCENT CELLS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/069000    International Application No.:    PCT/US2005/001471
Publication Date: 28.07.2005 International Filing Date: 13.01.2005
IPC:
G01N 33/50 (2006.01), G01N 33/574 (2006.01)
Applicants: EISAI CO. LTD. [JP/JP]; 6-10, Koishikawa 4-Chome, Bunkyo-ku, Tokyo 112-8088 (JP) (For All Designated States Except US).
LITTLEFIELD, Bruce, A. [US/US]; (US) (For US Only).
SALVATO, Kathleen, A. [US/US]; (US) (For US Only).
RUDOLPH-OWEN, Laura [US/US]; (US) (For US Only)
Inventors: LITTLEFIELD, Bruce, A.; (US).
SALVATO, Kathleen, A.; (US).
RUDOLPH-OWEN, Laura; (US)
Agent: LYON, Charles, E.; Patent Group, Choate, Hall & Stewart LLP, Two International Place, Boston, MA 02110 (US)
Priority Data:
60/536,196 13.01.2004 US
Title (EN) METHODS OF IDENTIFYING CYTOTOXIC EFFECTS IN QUIESCENT CELLS
(FR) PROCEDES D'IDENTIFICATION D'EFFETS CYTOTOXIQUES DANS DES CELLULES QUIESCENTES
Abstract: front page image
(EN)The present invention provides a system for measuring the cytotoxicity of a test compound against quiescent cells. The inventive methods and reagents may also be used to determine whether a compound, such as a chemotherapeutic agent, will have undesired toxicity toward normal tissues, which generally do not include a significant number of cells that are proliferating. Thus, the assay of the invention can be used to identify in vitro compounds that demonstrate a good therapeutic index, thus, accelerating the development of drugs that are clinically useful.
(FR)L'invention concerne un système de mesure de la cytotoxicité de composé d'essai par rapport à des cellules quiescentes. Les procédés et réactifs décrits peuvent également servir à déterminer si un composé, du type agent chimiothérapeutique, aura la même toxicité non désirée vis-à-vis de tissus normaux ne comprenant généralement pas un nombre important de cellules qui prolifèrent. L'essai considéré dans la présente invention peut être utilisé pour l'identification de composés in vitro qui présentent un bon indice thérapeutique, accélérant donc la mise au point de médicaments utiles du point de vue clinique.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)