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1. (WO2005068632) EPITOPE/PEPTIDE RECOGNIZED BY HLA-A2402-RESTRICTED Ep-CAM-SPECIFIC CTL AND USE OF THE SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/068632    International Application No.:    PCT/JP2005/000587
Publication Date: 28.07.2005 International Filing Date: 19.01.2005
IPC:
A61K 39/00 (2006.01)
Applicants: AICHI PREFECTURE [JP/JP]; 1-2, Sannomaru 3-chome, Naka-ku, Nagoya-shi, Aichi 4608501 (JP) (For All Designated States Except US).
OTSUKA PHARMACEUTICAL CO., LTD. [JP/JP]; 9, Kandatsukasa-cho 2-chome, Chiyoda-ku, Tokyo 1018535 (JP) (For All Designated States Except US).
KUZUSHIMA, Kiyotaka [JP/JP]; (JP) (For US Only)
Inventors: KUZUSHIMA, Kiyotaka; (JP)
Agent: SAEGUSA, Eiji; Kitahama TNK Building, 1-7-1, Doshomachi, Chuo-ku, Osaka-shi, Osaka 5410045 (JP)
Priority Data:
2004-011752 20.01.2004 JP
Title (EN) EPITOPE/PEPTIDE RECOGNIZED BY HLA-A2402-RESTRICTED Ep-CAM-SPECIFIC CTL AND USE OF THE SAME
(FR) EPITOPE/PEPTIDE RECONNU PAR CTL SPECIFIQUE DE EP-CAM A RESTRICTION HLA-A2402 ET SON UTILISATION
(JA) HLA−A2402拘束性Ep−CAM特異的CTLが認識するエピトープ・ペプチド及びその用途
Abstract: front page image
(EN)A peptide comprising the amino acid sequence represented by SEQ ID NO:1; a peptide comprising the amino acid sequence represented by SEQ ID NO:2; or a mutant peptide comprising an amino acid sequence derived from an amino acid sequence represented by SEQ ID NO:1 or 2 by addition, deletion or substitution of one or more amino acids and being capable of forming a complex with an HLA-A2402 molecule that can be recognized by HLA-A2402-restricted cytotoxic T lymphocytes or being capable of inducing the same. Such a peptide is useful as a cancer vaccine for epithelial cancer patients having HLA-A2402.
(FR)L'invention concerne un peptide contenant la séquence d'acides aminés représentée par SEQ ID NO:1, un peptide contenant la séquence d'acides aminés représentée par SEQ ID NO:2; ou un peptide mutant contenant une séquence d'acides aminés dérivée d'une séquence d'acides aminés représentée par SEQ ID NO:1 ou 2 par addition, délétion ou substitution d'un ou de plusieurs acides aminés, et étant capable de former un complexe avec une molécule HLA-A2402 pouvant être reconnue par les lymphocytes T cytotoxiques à restriction HLA-A2402 ou étant capable de l'induire. Ledit peptide est utile en tant que vaccin anticancéreux chez des patients atteints d'un cancer épithélial présentant un HLA-A2402.
(JA) 配列番号1のアミノ酸配列からなるペプチド;配列番号2のアミノ酸配列からなるペプチド;又は配列番号1若しくは2において1若しくは2以上のアミノ酸が付加、欠失又は置換されたアミノ酸配列からなり、かつHLA−A2402分子と複合してHLA−A2402拘束性細胞傷害性Tリンパ球に認識され得る又はこれを誘導し得る変異体ペプチドは、HLA−A2402を有する上皮性癌患者に対する癌ワクチンとして有用である。
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)