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1. (WO2005068619) GENERATION OF SPECIFIC ADHESION IN GRAM-NEGATIVE BACTERIA BY MEANS OF ANCHORING IMMUNOGLOBULIN SINGLE DOMAINS ON THEIR SURFACE WITH AUTOTRANSPORTERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/068619    International Application No.:    PCT/EP2005/000444
Publication Date: 28.07.2005 International Filing Date: 13.01.2005
Chapter 2 Demand Filed:    07.11.2005    
IPC:
C07K 16/00 (2006.01), C07K 16/12 (2006.01), C07K 16/46 (2006.01), C12N 1/20 (2006.01), C12N 9/52 (2006.01)
Applicants: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS [ES/ES]; Serrano, 117, E-28006 Madrid (ES) (For All Designated States Except US).
VEIGA CHACÓN, Esteban [ES/ES]; (ES) (For US Only).
DE LORENZO PRIETO, Víctor [ES/ES]; (ES) (For US Only).
FERNÁNDEZ HERRERO, Luis Angel [ES/ES]; (ES) (For US Only)
Inventors: VEIGA CHACÓN, Esteban; (ES).
DE LORENZO PRIETO, Víctor; (ES).
FERNÁNDEZ HERRERO, Luis Angel; (ES)
Agent: ARIAS SANZ, Juan; ABG Patentes, S.L., Orense, 68, 7th floor, E-28020 Madrid (ES)
Priority Data:
P200400073 14.01.2004 ES
Title (EN) GENERATION OF SPECIFIC ADHESION IN GRAM-NEGATIVE BACTERIA BY MEANS OF ANCHORING IMMUNOGLOBULIN SINGLE DOMAINS ON THEIR SURFACE WITH AUTOTRANSPORTERS
(FR) PRODUCTION D'ADHERENCE SPECIFIQUE DANS DES BACTERIES GRAM NEGATIF PAR FIXATION DE DOMAINES UNIQUES D'IMMUNOGLOBULINES SUR LA SURFACE DESDITES BACTERIES AU MOYEN D'AUTOTRANSPORTEURS
Abstract: front page image
(EN)The present invention refers to an expression vector for gram-negative bacteria allowing for the production of hybrid proteins between single domain recombinant antibodies and a transporter domain of an autotransporter, as well as to its anchoring and expression on the external surface of a bacterial membrane, and to a method of specific bacterial adhesion to a surface containing a specific antigen.
(FR)L'invention concerne un vecteur d'expression pour des bactéries Gram négatif permettant de produire des protéines hybrides entre des anticorps recombinés à domaine unique et un domaine de transport d'un autotransporteur, ainsi que sa fixation et que son expression sur la surface extérieure d'une membrane bactérienne, et un procédé d'adhérence bactérienne spécifique à une surface contenant un antigène spécifique.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)