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1. (WO2005068458) FIVE-MEMBERED HETEROCYCLIC COMPOUNDS AS INHIBITORS OF SRC FAMILY PROTEIN KINASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/068458    International Application No.:    PCT/EP2005/000335
Publication Date: 28.07.2005 International Filing Date: 14.01.2005
IPC:
C07D 417/04 (2006.01), C07D 417/12 (2006.01)
Applicants: SIRENADE PHARMACEUTICALS AG [DE/DE]; Am Klopferspitz 19, 82152 Martinsried (DE) (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NA, NE, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, YU, ZA, ZM, ZW only).
MIKSCH, Christian [DE/DE]; (DE) (For US Only).
BOSSE, Folkert [DE/DE]; (DE) (For US Only).
HOHLFELD, Thomas [DE/DE]; (DE) (For US Only).
SCHEUFLER, Clemens [DE/DE]; (DE) (For US Only).
OBERMEIER, Axel [DE/DE]; (DE) (For US Only).
MOAREFI, Ismail [DE/DE]; (DE) (For US Only).
KOSTKA, Thomas [DE/DE]; (DE) (For US Only).
MONSE, Barbara [DE/DE]; (DE) (For US Only)
Inventors: MIKSCH, Christian; (DE).
BOSSE, Folkert; (DE).
HOHLFELD, Thomas; (DE).
SCHEUFLER, Clemens; (DE).
OBERMEIER, Axel; (DE).
MOAREFI, Ismail; (DE).
KOSTKA, Thomas; (DE).
MONSE, Barbara; (DE)
Agent: GRAF VON STOSCH, Andreas; Bosch, Graf von Stosch, Jehle, Flüggenstr. 13, 80639 München (DE)
Priority Data:
04000762.7 15.01.2004 EP
Title (EN) FIVE-MEMBERED HETEROCYCLIC COMPOUNDS AS INHIBITORS OF SRC FAMILY PROTEIN KINASE
(FR) COMPOSES INHIBITEURS DE KINASES
Abstract: front page image
(EN)The present invention refers to novel substituted aromatic heteroaryl derivatives of formula (I), with the definitions of a, L1, L2, G, J, X and Y according to claim 1. These novel compounds are useful for the inhibition of protein kinases, particularly of the inhibition of Src family protein kinases. Methods for inhibiting kinases by contacting kinases with these novel compounds are disclosed. In another embodiment the present invention refers to pharmaceutical compositions containing these novel compounds and their use of medicaments for treating diseases or disorders associated with unphysiological activity of kinases in the body, particularly for the treatment of cancer, immunosuppression, and osteoporosis.
(FR)La présente invention concerne des nouveaux composés fondés sur un système de noyau hétéroaryle aromatique substitué. Ces nouveaux composés sont utiles pour inhiber les protéines kinases, en particulier, pour inhiber les protéines kinases de la famille de Src. Cette invention concerne également des procédés permettant d'inhiber des kinases par mise en contact de kinases avec ces nouveaux composés. Un autre mode de réalisation concerne des compositions pharmaceutiques comprenant ces nouveaux composés, ainsi que leur utilisation pour la préparation de médicaments permettant de traiter des maladies ou des troubles associés à une activité non physiologique des kinases dans le corps, plus particulièrement, pour traiter le cancer, l'immunodépression et l'ostéoporose.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)