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1. (WO2005068442) ISOXAZOLE DERIVATIVES AND THEIR USE AS CYCLOOXYGENASE INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/068442    International Application No.:    PCT/IB2005/000047
Publication Date: 28.07.2005 International Filing Date: 12.01.2005
IPC:
A61K 31/42 (2006.01), C07D 261/08 (2006.01), C07D 413/04 (2006.01)
Applicants: UNIVERSITA DEGLI STUDI DI BARI [IT/IT]; Piazza Umberto I, 1, I-70121 Bari (IT) (For All Designated States Except US).
UNIVERSITA' DEGLI STUDI DI CHIETI [IT/IT]; G. D'Annunzio, Via dei Vestini 31, I-66013 Chieti (IT) (For All Designated States Except US).
SCILIMATI, Antonio [IT/IT]; (IT) (For US Only).
DI NUNNO, Leonardo [IT/IT]; (IT) (For US Only).
VITALE, Paola [IT/IT]; (IT) (For US Only).
PATRIGNANI, Paola [IT/IT]; (IT) (For US Only).
TACCONELLI, Stefania [IT/IT]; (IT) (For US Only).
PORRECA, Ettore [IT/IT]; (IT) (For US Only).
STUPPIA, Liborio [IT/IT]; (IT) (For US Only)
Inventors: SCILIMATI, Antonio; (IT).
DI NUNNO, Leonardo; (IT).
VITALE, Paola; (IT).
PATRIGNANI, Paola; (IT).
TACCONELLI, Stefania; (IT).
PORRECA, Ettore; (IT).
STUPPIA, Liborio; (IT)
Agent: TRUPIANO, Federica; Marietti, Gislon e Trupiano S.r.l., Via Larga, 16, I-20122 Milan (IT)
Priority Data:
MI2004A000019 12.01.2004 IT
Title (EN) ISOXAZOLE DERIVATIVES AND THEIR USE AS CYCLOOXYGENASE INHIBITORS
(FR) DERIVES ISOXAZOLE ET UTILISATION EN TANT QU'INHIBITEURS DE CYCLOOXYGENASE
Abstract: front page image
(EN)The present invention refers to isoxazole derivatives, in particular 3,4-diaryl isoxazole derivatives, to their pharmaceutical compositions, the process for preparing them and their use as inhibitors of cycloosygenase, in particular of cycloosygenase 1 and 2 (COX-1) (COX-2). The present invention also refers to a process for determining the potential toxicity of compounds that inhibit cycloosygenase (COX), in particular cycloosygenase-2 (COX-2) isoform, and to the use of compounds that inhibit cycloosygenase (COX), in particular cycloosygenase-2 (COX-2) and their pharmaceutical compositions, in subjects for whom the potential cardiovascular toxicity of said compounds is reduced.
(FR)La présente invention concerne des dérivés isoxazole, notamment des dérivés 3,4-diaryl isoxazole, des compositions pharmaceutiques les contenant, leur procédé de fabrication et leur utilisation en tant qu'inhibiteurs de cyclooxygénase, notamment de cyclooxygénase 1 et 2 (COX-1, COX-2). La présente invention concerne également un procédé de détermination de la toxicité potentielle de composés inhibant cyclooxygénase (COX), en particulier l'isoforme cyclooxygénase 2 (COX-2), et l'utilisation de composés inhibant cyclooxygénase (COX), en particulier cyclooxygénase 2 (COX-2), et de leurs compositions pharmaceutiques, chez des sujets pour lesquels la toxicité cardiovasculaire desdits composés est réduite.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: Italian (IT)