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1. (WO2005068415) PHENYLALANINE DERIVATIVE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/068415    International Application No.:    PCT/JP2005/000666
Publication Date: 28.07.2005 International Filing Date: 20.01.2005
IPC:
C07C 233/51 (2006.01)
Applicants: FUJIYAKUHIN CO., LTD. [JP/JP]; 383, SAKURAGICHO 4-CHOME OMIYA-KU, SAITAMA-SHI Saitama 3300854 (JP) (For All Designated States Except US).
UDA, Junichiro [JP/JP]; (JP) (For US Only).
OKAMOTO, Yasushi [JP/JP]; (JP) (For US Only).
IWABUCHI, Takeyuki [JP/JP]; (JP) (For US Only).
INOUE, Tsutomu [JP/JP]; (JP) (For US Only).
NAKANO, Hiroyuki [JP/JP]; (JP) (For US Only).
ISHIKAWA, Tomohiko [JP/JP]; (JP) (For US Only).
KAWASAKI, Nobuhide [JP/JP]; (JP) (For US Only).
KATOH, Masumi [JP/JP]; (JP) (For US Only)
Inventors: UDA, Junichiro; (JP).
OKAMOTO, Yasushi; (JP).
IWABUCHI, Takeyuki; (JP).
INOUE, Tsutomu; (JP).
NAKANO, Hiroyuki; (JP).
ISHIKAWA, Tomohiko; (JP).
KAWASAKI, Nobuhide; (JP).
KATOH, Masumi; (JP)
Agent: THE PATENT CORPORATE BODY ARUGA PATENT OFFICE; KYODO BLDG. 3-6 NIHONBASHININGYOCHO 1-CHOME CHUO-KU, Tokyo 1030013 (JP)
Priority Data:
2004-011824 20.01.2004 JP
Title (EN) PHENYLALANINE DERIVATIVE
(FR) DERIVE DE PHENYLALANINE
(JA) フェニルアラニン誘導体
Abstract: front page image
(EN)Disclosed is a phenylalanine derivative having excellent VLA-4 inhibitory activity which is represented by the following general formula (1) or a salt thereof. (1) (In the formula, R1 represents an aromatic hydrocarbon group having 6-10 carbon atoms or the like; Z represents a phenyl group or the like; R2 represents a hydrogen atom or a lower alkyl group; n represents a number such as 0; and when n is 0, Y represents NOR3 (wherein R3 represents a methyl group or the like), CCl2 or the like.)
(FR)La présente invention se rapporte à un dérivé de phénylalanine possédant une excellente activité inhibitrice de VLA-4, qui est représentée par la formule générale suivante (I) ou à un sel de ce dérivé. Dans la formule (I), R1 représente un groupe hydrocarboné aromatique ayant de 6 à 10 atomes de carbone ou analogue; Z représente un groupe phényle ou analogue; R2 représente un atome d'hydrogène ou un groupe alkyle inférieur; n représente un nombre tel que 0; et lorsque n est égal à 0, Y représente NOR3 (où R3 représente un groupe méthyle ou analogue), CCl2 ou analogue).
(JA)not available
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)