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1. (WO2005067982) METHODS FOR IMAGING THE LYMPHATIC SYSTEM USING DENDRIMER-BASED CONTRAST AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/067982    International Application No.:    PCT/US2005/001388
Publication Date: 28.07.2005 International Filing Date: 12.01.2005
IPC:
A61K 49/00 (2006.01), A61K 49/08 (2006.01), A61K 49/12 (2006.01)
Applicants: THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES [US/US]; National Institutes of Health, Office of Technology Transfer, Suite 325, 6011 Executive Boulevard, Rockville, MD 29852-3804 (US) (For All Designated States Except US).
BRECHBIEL, Martin, W. [US/US]; (US) (For US Only).
KOBAYASHI, Hisataka [JP/JP]; (JP) (For US Only).
CHOYKE, Peter, L. [US/US]; (US) (For US Only).
MORRIS, John, C. [US/US]; (US) (For US Only).
WALDMANN, Thomas, A. [US/US]; (US) (For US Only)
Inventors: BRECHBIEL, Martin, W.; (US).
KOBAYASHI, Hisataka; (JP).
CHOYKE, Peter, L.; (US).
MORRIS, John, C.; (US).
WALDMANN, Thomas, A.; (US)
Agent: STEPHENS, Donald, L., Jr.; Klarquist Sparkman, LLP, Suite 1600, One World Trade Center, 121 SW Salmon Street, Portland, OR 97204 (US)
Priority Data:
10/756,948 13.01.2004 US
Title (EN) METHODS FOR IMAGING THE LYMPHATIC SYSTEM USING DENDRIMER-BASED CONTRAST AGENTS
(FR) PROCEDES POUR L'IMAGERIE DU SYSTEME LYMPHATIQUE A L'AIDE D'AGENTS DE CONTRASTE A BASE DE DENDRIMERES
Abstract: front page image
(EN)Methods are disclosed for lymphatic-system imaging using dendrimer conjugates as contrast agents. The disclosed methods are applicable to the imaging of all lymphatic structures, but in particular embodiments are particularly suited for imaging specific parts of the lymphatic system such as lymph nodes or lymphatic vessels. The methods permit the assessment of abnormal conditions within the lymphatic system, such as lymphoma/lymphoproliferative disease, inflammation, and cancer metastasis. The methods also may be used to identify and locate lymph nodes into which lymph fluid flows from a tumor.
(FR)L'invention concerne des procédés pour l'imagerie du système lymphatique à l'aide de conjugués de dendrimères en tant qu'agents de contraste. Les procédés selon l'invention conviennent à l'imagerie de toutes les structures lymphatiques, mais certains modes de réalisation de l'invention conviennent particulièrement à l'imagerie de parties spécifiques du système lymphatique, telles que les ganglions lymphatiques ou les vaisseaux lymphatiques. Les procédés selon l'invention permettent d'évaluer des états anormaux à l'intérieur du système lymphatique, par exemple un lymphome/une maladie lymphoproliférative, une inflammation et une métastase cancéreuse. Ces procédés peuvent également servir à identifier et à localiser des ganglions lymphatiques dans lesquels du liquide lymphatique s'écoule d'une tumeur.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)