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1. (WO2005067937) NEUTRAL ENDOPEPTIDASE (NEP) AND HUMAN SOLUBLE ENDOPEPTIDASE (HSEP) INHIBITORS FOR PROPHYLAXIS AND TREATMENT OF NEURODEGENERATIVE DISORDERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/067937    International Application No.:    PCT/EP2005/050075
Publication Date: 28.07.2005 International Filing Date: 10.01.2005
Chapter 2 Demand Filed:    16.06.2005    
IPC:
A61K 31/55 (2006.01)
Applicants: SOLVAY PHARMACEUTICALS B.V. [NL/NL]; C.J. van Houtenlaan 36, NL-1381 CP Weesp (NL) (For All Designated States Except US).
WESKE, Michael [DE/DE]; (NL) (For US Only).
TURSKI, Lechoslaw A. [DE/DE]; (NL) (For US Only).
IKONOMIDOU, Hrissanthi [DE/DE]; (NL) (For US Only).
ZIEGLER, Dieter [DE/DE]; (NL) (For US Only)
Inventors: WESKE, Michael; (NL).
TURSKI, Lechoslaw A.; (NL).
IKONOMIDOU, Hrissanthi; (NL).
ZIEGLER, Dieter; (NL)
Agent: VERHAGE, Marinus; C.J. van Houtenlaan 36, NL-1381 CP Weesp (NL)
Priority Data:
60/535,538 12.01.2004 US
04100067.0 12.01.2004 EP
Title (EN) NEUTRAL ENDOPEPTIDASE (NEP) AND HUMAN SOLUBLE ENDOPEPTIDASE (HSEP) INHIBITORS FOR PROPHYLAXIS AND TREATMENT OF NEURODEGENERATIVE DISORDERS
(FR) INHIBITEURS DE L'ENDOPEPTIDASE NEUTRE (NEP) ET DE L'ENDOPEPTIDASE SOLUBLE HUMAINE (HSEP) ET TRAITEMENT DES TROUBLES NEURODEGENERATIFS
Abstract: front page image
(EN)The invention relates to a novel use of known benzazepine, benzoxazepine, benzothiazepine-N-acetic acid and phosphono-substituted benzazepinone derivatives having neutral endopeptidase (NEP) and/or human soluble endopeptidase (hSEP) inhibitory activity. The compounds of the invention are useful for the preparation of pharmaceutical compositions for prophylaxis and treatment of neurodegenerative disorders. The compounds of the invention are known from the European patents EP 0 733 642 and EP 0 916 679, and can be described by the general formula (1) wherein the symbols have the meanings as given above in the description.
(FR)L'invention concerne une nouvelle utilisation de dérivés connus de la benzazépine, de la benzoxazépine, de l'acide benzothiazépine-N-acétique et de la benzazépinone phosphono-substituée possédant une activité inhibitrice de l'endopeptidase neutre (NEP) et/ou de l'endopeptidase soluble humaine (hSEP). Les composés de l'invention sont utilisés dans la préparation de compositions pharmaceutiques destinées à la prophylaxie et au traitement des troubles neurodégénératifs. Les composés de l'invention, connus dans le cadre des brevets européens EP 0 733 642 et EP 0 916 679, peuvent être décrits par la formule générale (1) dans laquelle les symboles possèdent les significations données dans la description.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)