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1. WO2005067922 - A PROCESS FOR THE PREPARATION OF 4-(2-DIPROPYLAMINOETHYL)-1,3-DIHYDRO-2H-INDOL-2-ONE HYDROCHLORIDE

Publication Number WO/2005/067922
Publication Date 28.07.2005
International Application No. PCT/IN2004/000214
International Filing Date 16.07.2004
Chapter 2 Demand Filed 04.10.2005
IPC
C07D 209/34 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
209Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02condensed with one carbocyclic ring
04Indoles; Hydrogenated indoles
30with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
32Oxygen atoms
34in position 2
C07D 209/48 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
209Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02condensed with one carbocyclic ring
44Iso-indoles; Hydrogenated iso-indoles
48with oxygen atoms in positions 1 and 3, e.g. phthalimide
C07D 403/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
CPC
C07D 209/34
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
209Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02condensed with one carbocyclic ring
04Indoles; Hydrogenated indoles
30with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
32Oxygen atoms
34in position 2
C07D 209/48
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
209Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02condensed with one carbocyclic ring
44Iso-indoles; Hydrogenated iso-indoles
48with oxygen atoms in positions 1 and 3, e.g. phthalimide
Applicants
  • USV LIMITED [IN]/[IN] (AllExceptUS)
  • TARUR, Venkatasubramanian, Radhakrishnan [IN]/[IN] (UsOnly)
  • SATHE, Dhananjay, Govind [IN]/[IN] (UsOnly)
  • MONDKAR, Harish, Kashinath [IN]/[IN] (UsOnly)
  • BHOPALKAR, Rajesh, Ganpat [IN]/[IN] (UsOnly)
  • PATIL, Samadhan, Daulat [IN]/[IN] (UsOnly)
Inventors
  • TARUR, Venkatasubramanian, Radhakrishnan
  • SATHE, Dhananjay, Govind
  • MONDKAR, Harish, Kashinath
  • BHOPALKAR, Rajesh, Ganpat
  • PATIL, Samadhan, Daulat
Agents
  • LAKSHMIKUMARAN V
Priority Data
60/MUM/200420.01.2004IN
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) A PROCESS FOR THE PREPARATION OF 4-(2-DIPROPYLAMINOETHYL)-1,3-DIHYDRO-2H-INDOL-2-ONE HYDROCHLORIDE
(FR) PROCEDE SERVANT A PREPARER 4-(2-DIPROPYLAMINOETHYL)-1,3-DIHYDRO-2H-INDOL-2-ONE CHLORHYDRATE
Abstract
(EN)
The present invention discloses a novel process and novel intermediates for the Preparation of 4-[2-(di -n-propyl amino) ethyl]-1,3-dihydro-2H-indol-2-one, commonly known as Ropinirole (I) and pharmaceutical composition comprising the same. Further the present invention also discloses a method of treatment for cardiovascular disorders and Parkinson’s disease.
(FR)
L'invention concerne un nouveau procédé et de nouveaux intermédiaires servant à préparer 4-[2-(di-n-propylamino)éthyl]-1,3-dihydro-2H-indol-2-one, désigné communément ropinirole (I), ainsi qu'une composition pharmaceutique contenant ce dernier. Elle concerne également une méthode servant à traiter des maladies cardio-vasculaires et la maladie de Parkinson.
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