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1. (WO2005067667) BIOMARKERS AND METHODS FOR DETERMINING SENSITIVITY TO EPIDERMAL GROWTH FACTOR RECEPTOR MODULATORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/067667    International Application No.:    PCT/US2005/000638
Publication Date: 28.07.2005 International Filing Date: 07.01.2005
IPC:
C12Q 1/00 (2006.01), C12Q 1/68 (2006.01)
Applicants: BRISTOL-MYERS SQUIBB COMPANY [US/US]; Route 206 and Province Line Road, Princeton, NJ 08543-4000 (US) (For All Designated States Except US).
CLARK, Edwin, A. [US/US]; (US) (For US Only).
FORD, Shirin, K. [IN/US]; (US) (For US Only).
YOGANATHAN, Suganthy [LK/US]; (US) (For US Only).
JACKSON, Donald, G. [US/US]; (US) (For US Only)
Inventors: CLARK, Edwin, A.; (US).
FORD, Shirin, K.; (US).
YOGANATHAN, Suganthy; (US).
JACKSON, Donald, G.; (US)
Agent: GOLIAN, Paul, D.; Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, NJ 08543-4000 (US)
Priority Data:
60/535,151 07.01.2004 US
Title (EN) BIOMARKERS AND METHODS FOR DETERMINING SENSITIVITY TO EPIDERMAL GROWTH FACTOR RECEPTOR MODULATORS
(FR) BIOMARQUEURS ET METHODES SERVANT A DETERMINER LA SENSIBILITE A DES MODULATEURS DU RECEPTEUR DU FACTEUR DE CROISSANCE EPIDERMIQUE
Abstract: front page image
(EN)EGFR biomarkers useful in a method for identifying a mammal that will respond therapeutically to a method of treating cancer comprising administering an EGFR modulator, wherein the method comprises (a) exposing the mammal to the EGFR modulator and (b) measuring in the mammal the level of the at least one biomarker, wherein a difference in the level of the at least one biomarker measured in (b) compared to the level of the biomarker in a mammal that has not been exposed to the EGFR modulator indicates that the mammal will respond therapeutically to the method of treating cancer.
(FR)Biomarqueurs de EGFR utiles dans une méthode servant à identifier un mammifère qui présentera une réponse thérapeutique positive à un traitement du cancer consistant à administrer un modulateur de EGFR. Cette méthode consiste, plus particulièrement à (a) exposer ce mammifère au modulateur de EGFR et (b) mesurer chez ce mammifère le niveau du biomarqueur, une différence de niveau de ce biomarqueur mesuré à l'étape (b) par rapport au niveau du biomarqueur chez un mammifère n'ayant pas été exposé au modulateur de EGFR indiquant que ce mammifère présente une sensibilité thérapeutique au traitement du cancer.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)