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1. (WO2005067629) CANCER-LINKED GENES AS TARGETS FOR CHEMOTHERAPY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/067629    International Application No.:    PCT/US2005/000040
Publication Date: 28.07.2005 International Filing Date: 04.01.2005
Chapter 2 Demand Filed:    05.08.2005    
IPC:
C12Q 1/70 (2006.01), C12Q 1/68 (2006.01), A61K 48/00 (2006.01), A61K 39/395 (2006.01), A61K 39/00 (2006.01), G01N 33/543 (2006.01)
Applicants: AVALON PHARMACEUTICALS [US/US]; 20358 Seneca Meadows Parkway, Germantown, MD 20876 (US) (For All Designated States Except US).
WEIGLE, Bernd [DE/DE]; (DE) (For US Only).
EBNER, Reinhard [US/US]; (US) (For US Only)
Inventors: WEIGLE, Bernd; (DE).
EBNER, Reinhard; (US)
Agent: GRANT, Alan, J.; Carella, Byrne, Bain, Gilfillan, Cecchi, Stewart & Olstein, 5 Becker Farm Road, Roseland, NJ 07068 (US)
Priority Data:
60/534,419 06.01.2004 US
Title (EN) CANCER-LINKED GENES AS TARGETS FOR CHEMOTHERAPY
(FR) GENES LIES AU CANCER EN TANT QUE CIBLES POUR LA CHIMIOTHERAPIE
Abstract: front page image
(EN)Cancer-linked gene sequences, and derived amino acid sequences, are disclosed along with processes for assaying potential antitumor agents based on their modulation of the expression of these cancer-linked genes. Also disclosed are antibodies that react with the disclosed polypeptides and methods of using the antibodies to treat cancerous conditions, such as by using the antibody to target cancerous cells in vivo for purposes of delivering therapeutic agents thereto. Also described are methods of diagnosing using the gene sequences as well as the polypeptide sequences, especially for diagnosing prostate cancer.
(FR)La présente invention concerne des séquences géniques liées au cancer, et des séquences d'acides aminés dérivées, ainsi que des procédés pour tester des agents antitumoraux potentiels en se basant sur leur aptitude à moduler l'expression de ces gènes liés au cancer. L'invention a également pour objet des anticorps qui réagissent avec les polypeptides de l'invention, et des procédés pour utiliser ces anticorps pour traiter des états pathologiques cancéreux, par exemple par utilisation de l'anticorps pour cibler des cellules cancéreuses cibles <i>in vivo</i> afin de leurs administrer des agents thérapeutiques. L'invention a également pour objet des procédés de diagnostic au moyen des séquences géniques et des séquences polypeptidiques, en particulier pour diagnostiquer le cancer de la prostate.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)