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1. WO2005067564 - 6-11 BICYCLIC ERYTHROMYCIN DERIVATIVES

Publication Number WO/2005/067564
Publication Date 28.07.2005
International Application No. PCT/US2005/000153
International Filing Date 05.01.2005
IPC
A61K 31/70 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
C07H 17/08 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
17Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
04Heterocyclic radicals containing only oxygen as ring hetero atoms
08Hetero rings containing eight or more ring members, e.g. erythromycins
CPC
C07H 17/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
17Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
04Heterocyclic radicals containing only oxygen as ring hetero atoms
08Hetero rings containing eight or more ring members, e.g. erythromycins
Applicants
  • ENANTA PHARMACEUTICALS, INC. [US]/[US] (AllExceptUS)
  • WANG, Guoqiang [CN]/[US] (UsOnly)
  • VO, Nha, Huu [US]/[US] (UsOnly)
  • XU, Guoyou [CN]/[US] (UsOnly)
  • HOU, Ying [CN]/[US] (UsOnly)
  • SUN, Ying [CN]/[US] (UsOnly)
  • PHAN, Ly, Tam [US]/[US] (UsOnly)
  • WANG, Zhe [US]/[US] (UsOnly)
  • OR, Yat, Sun [US]/[US] (UsOnly)
Inventors
  • WANG, Guoqiang
  • VO, Nha, Huu
  • XU, Guoyou
  • HOU, Ying
  • SUN, Ying
  • PHAN, Ly, Tam
  • WANG, Zhe
  • OR, Yat, Sun
Agents
  • CRAIG, Anne, I.
Priority Data
60/534,88507.01.2004US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) 6-11 BICYCLIC ERYTHROMYCIN DERIVATIVES
(FR) DERIVES D'ERYTHROMYCINE 6-11 BICYCLIQUE
Abstract
(EN) The present invention discloses compounds of formulaes I, II, III, or IV, or a 5 racemate, enantiomer, regioisomer, salt, ester or prodrug thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
(FR) La présente invention concerne des composés des formules I, II, III ou IV ou un racémate 5, énantiomère, régio-isomère, sel, éther ou promédicament de ces derniers et ayant des propriétés antibactériennes. La présente invention concerne également des compositions pharmaceutiques contenant les composés susmentionnés et destinées à être administrées à un patient nécessitant un traitement antibiotique. L'invention concerne également des procédés de traitement d'une infection bactérienne chez un patient par l'administration d'une composition pharmaceutique contenant les composés de la présente invention. L'invention concerne également un procédé de production des composés de la présente invention.
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