WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2005066215) COHESIVE GELS FORM CROSS-LINKED HYALURONAN AND/OR HYLAN, THEIR PREPARATION AND USE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/066215    International Application No.:    PCT/US2004/043811
Publication Date: 21.07.2005 International Filing Date: 30.12.2004
IPC:
A61K 9/00 (2006.01), A61K 31/728 (2006.01), A61K 47/36 (2006.01), C08B 37/08 (2006.01)
Applicants: GENZYME CORPORATION [US/US]; 500 Kendall Street, Cambridge, MA 02142 (US) (For All Designated States Except US).
LESHCHINER, Adelya, K. [US/US]; (US) (For US Only).
KONOWICZ, Paul, A. [US/US]; (US) (For US Only).
VASILYEVA, Valentina [US/US]; (US) (For US Only)
Inventors: LESHCHINER, Adelya, K.; (US).
KONOWICZ, Paul, A.; (US).
VASILYEVA, Valentina; (US)
Agent: COBERT, Robert, J.; GENZYME CORPORATION Legal Department, 500 Kendall Street, Cambridge, MA 02142 (US)
Priority Data:
60/533,429 30.12.2003 US
Title (EN) COHESIVE GELS FORM CROSS-LINKED HYALURONAN AND/OR HYLAN, THEIR PREPARATION AND USE
(FR) GELS COHESIFS DE HYALURONANE ET/OU HYLANE RETICULES, PREPARATION ET UTILISATION
Abstract: front page image
(EN)Disclosed are highly resilient and cohesive gels formed by the cross-linking of hyaluronan or hylan, their salts or derivatives thereof, using divinyl sulfone (DVS) as the cross-linking agent. Also disclosed are viscoelastic fluids containing alkylsulfone groups covalently attached to the backbone of the polymer, formed by the mono-functionalization of the cross-linking monomer DVS with hyaluronan and/or hylan. Mechanical properties such as values of hardness and cohesiveness are specified by the rheological properties of the gels. Also disclosed are methods for the preparation of such products. They have use in many applications as injectable and/or implantable devices and as drug delivery systems.
(FR)L'invention concerne des gels hautement élastiques et cohésifs formés par réticulation de hyaluronane ou de hylane, de leurs sels ou de dérivés de ceux-ci, à l'aide de sulfone de divinyle (DVS) comme agent de réticulation. L'invention concerne également des fluides viscoélastiques contenant des groupes d'alkylsulfone rattachés par covalence au squelette du polymère, formés par monofonctionnalisation du monomère DVS de réticulation avec l'hyaluronane et/ou l'hylane. Des propriétés mécaniques telles que les valeurs de dureté et de cohésion sont spécifiées par les propriétés rhéologiques des gels. L'invention concerne en outre des procédés de préparation desdits produits. Ils sont utilisés dans de nombreuses applications comme dispositifs injectables et/ou implantables et comme systèmes d'administration de médicaments.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)