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1. (WO2005066188) A PROCESS FOR THE PREPARATION OF 2-(IMIDAZOL-1-YL)-1-HYDROXYETHANE-1, 1-DIPHOSPHONIC ACID
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/066188    International Application No.:    PCT/IN2004/000320
Publication Date: 21.07.2005 International Filing Date: 18.10.2004
Chapter 2 Demand Filed:    10.05.2005    
IPC:
C07F 9/6506 (2006.01)
Applicants: SUN PHARMACEUTICAL INDUSTRIES LIMITED [IN/IN]; Acme Plaza, Andheri Kurla Road, Andheri, AndheriEast, Mumbai 400 059 (IN) (For All Designated States Except US).
PATEL, Vijaykumar, Muljibhai [IN/IN]; (IN) (For US Only).
CHITTURI, Trinadha, Rao [IN/IN]; (IN) (For US Only).
THENNATI, Rajamannar [IN/IN]; (IN) (For US Only)
Inventors: PATEL, Vijaykumar, Muljibhai; (IN).
CHITTURI, Trinadha, Rao; (IN).
THENNATI, Rajamannar; (IN)
Priority Data:
1094/MUM/2003 17.10.2003 IN
Title (EN) A PROCESS FOR THE PREPARATION OF 2-(IMIDAZOL-1-YL)-1-HYDROXYETHANE-1, 1-DIPHOSPHONIC ACID
(FR) PROCEDE DE PREPARATION D'ACIDE 2-(IMIDAZOL-1-YL)-1-HYDROXYETHANE-1,1-DIPHOSPHONIQUE
Abstract: front page image
(EN)The present invention provides a process for preparation of 2-(imidazol-1-yl)-1-hydroxyethane-1,1-diphosphonic acid, compound of formula (1), said process comprising (a) reacting imidazole with chloroacetyl chloride and benzyl alcohol in homogenous system in one pot to obtain benzyl 1-imidazolylacetate, compound of formula (3); (b) debenzylating benzyl 1-imidazolylacetate, a compound of formula (3) to imidazole 1-ylacetic acid, compound of formula (2) and (c) converting compound of formula (2) to compound of formula (1).
(FR)L'invention concerne un procédé pour préparer le composé acide 2-(imidazol-1-yl)-1-hydroxyéthane-1,1-diphosphonique de formule (1). Ce procédé comprend les étapes qui consistent : (a) à faire réagir de l'imidazole avec du chlorure de chloroacétyle et de l'alcool de benzyle dans un système homogène dans un seul récipient, pour obtenir le composé benzyl 1-imidazolylacétate de formule (3) ; (b) à procéder à la débenzylation du composé benzyl 1-imidazolylacétate de formule (3) pour obtenir le composé acide 1-ylacétique de formule (2), et ; (c) à convertir le composé de formule (2) en composé de formule (1).
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)