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Machine translation
1. (WO2005066166) 3-QUINUCLIDINYL AMINO-SUBSTITUTED BIARYL DERIVATIVES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/066166    International Application No.:    PCT/US2004/041366
Publication Date: 21.07.2005 International Filing Date: 10.12.2004
IPC:
A61K 31/439 (2006.01), C07D 453/00 (2006.01)
Applicants: ABBOTT LABORATORIES [US/US]; Dept. 377 Bldg AP6A-1, 100 Abbott Park Road, Abbott Park, Illinois 60064-6008 (US) (For All Designated States Except US).
JI, Jianguo [CN/US]; (US) (For US Only).
LI, Tao [CN/US]; (US) (For US Only).
WANG, Ying [US/US]; (US) (For US Only)
Inventors: JI, Jianguo; (US).
LI, Tao; (US).
WANG, Ying; (US)
Agent: CHEN, Portia; Dept. 377 Bldg AP6A-1, 100 Abbott Park Road, Abbott Park, Illinois 60064-6008 (US)
Priority Data:
10/745,088 22.12.2003 US
Title (EN) 3-QUINUCLIDINYL AMINO-SUBSTITUTED BIARYL DERIVATIVES
(FR) DERIVES DE BIARYLE A SUBSTITUTION AMINO DE 3-QUINUCLIDINYLE
Abstract: front page image
(EN)Compounds of formula (I); wherein A is N or N+-O-; n is 0, 1, or 2; Y is O, S, -NH-, and -N-alkyl-; Ar1 is both 6-membered aromatic rings; Ar2 is 5- or 6-membered aromatic rings with a -NR8R9 group, as defined herein. The compounds are useful in treating conditions or disorders prevented by or ameliorated by &agr;7 nAChR ligands. Also disclosed are pharmaceutical compositions having compounds of formula (I) and methods for using such compounds and compositions.
(FR)La présente invention concerne des composés de formule (I) dans laquelle A représente N ou N+-O-; n vaut 0, 1 ou 2; Y représente O, S, -NH- et -N-alkyl-; Ar1 représente des noyaux aromatiques à 6 éléments; Ar2 représente des noyaux aromatiques à 5 ou 6 éléments avec un groupe -NR8R9. Ces composés sont utilisés pour traiter des pathologies ou des troubles que des ligands nAChR $g(a)7 permettent de prévenir ou d'améliorer. La présente invention concerne également des compositions pharmaceutiques comprenant des composés de formule (I), ainsi que des procédés pour utiliser ces composés et ces compositions.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)