WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2005066159) CATHEPSIN CYSTEINE PROTEASE INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/066159    International Application No.:    PCT/CA2005/000007
Publication Date: 21.07.2005 International Filing Date: 06.01.2005
IPC:
A61K 31/341 (2006.01), A61K 31/40 (2006.01), A61K 31/44 (2006.01), A61K 31/4433 (2006.01), A61K 31/445 (2006.01), A61K 31/506 (2006.01), A61K 31/55 (2006.01), A61P 19/08 (2006.01), C07D 207/24 (2006.01), C07D 211/74 (2006.01), C07D 213/65 (2006.01), C07D 309/30 (2006.01), C07D 401/12 (2006.01), C07D 403/12 (2006.01), C07D 405/12 (2006.01)
Applicants: MERCK FROSST CANADA LTD. [CA/CA]; 16711 Trans-Canada Highway, Kirkland, Québec H9H 3L1 (CA) (For All Designated States Except US).
BAYLY, Christopher [CA/CA]; (CA) (For US Only).
BLACK, Cameron [CA/CA]; (CA) (For US Only).
THERIEN, Michel [CA/CA]; (CA) (For US Only)
Inventors: BAYLY, Christopher; (CA).
BLACK, Cameron; (CA).
THERIEN, Michel; (CA)
Agent: OGILVY RENAULT LLP / S.E.N.C.R.L., S.R.L.; Suite 1600, 1981 McGill College Avenue, Montréal, Québec H3A 2Y3 (CA)
Priority Data:
60/534,920 08.01.2004 US
Title (EN) CATHEPSIN CYSTEINE PROTEASE INHIBITORS
(FR) INHIBITEURS DES CYSTEINES PROTEASES DE TYPE CATHEPSINE
Abstract: front page image
(EN)The present invention relates to a novel class of compounds mainly, leucinamide-amino-carboxylate derivatives of formula (I) wherein Y is CR1R2, O, S, -SO2, C=0 or NR9; Z is CR1R2, O, S, -SO2, C=O or NR9 and each G is independently a CR1CR2. Said compounds are cathepsin cysteine protease inhibitors, including but not limited to, inhibitors of cathepsin K, L, S and B and to pharmaceutical compositions thereof. These compounds are useful for treating and preventing cathepsin dependent conditions in which inhibition of bone resorption is indicated, such as osteoporosis.
(FR)La présente invention concerne une nouvelle classe de composés, essentiellement des dérivés de leucinamide-amino-carboxylate représentés par la formule (I) dans laquelle Y est CR1R2, O, S, -SO2, C=0 ou NR9; Z est CR1R2, O, S, -SO2, C=O ou NR9 et chaque G est indépendamment un CR1CR2. Lesdits composés sont des inhibiteurs des cystéines protéases de type cathepsine, y compris, entre autres, des inhibiteurs de la cathepsine K, L, S et B. L'invention concerne également des compositions pharmaceutiques desdits composés. Ces composés sont utilisés dans le traitement et la prévention d'états dépendant de la cathepsine dans lesquels est indiquée l'inhibition de la résorption osseuse, par exemple l'ostéoporose.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)