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1. (WO2005066152) THIOPHENE DERIVATIVES FOR UP-REGULATING HLA-DM ACTIVITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/066152    International Application No.:    PCT/US2004/043950
Publication Date: 21.07.2005 International Filing Date: 29.12.2004
IPC:
C07D 333/40 (2006.01), G01N 33/68 (2006.01)
Applicants: THE BRIGHAM AND WOMEN'S HOSPITAL, INC. [US/US]; 75 Francis Street, Boston, MA 02115 (US) (For All Designated States Except US).
DANA-FARBER CANCER INSTITUTE, INC. [US/US]; 44 Binney Street, Boston, MA 02155 (US) (For All Designated States Except US).
NICHOLSON, Melissa [NZ/US]; (US) (For US Only).
WUCHERPFENNIG, Kai [DE/US]; (US) (For US Only).
STEIN, Ross, L. [US/US]; (US) (For US Only).
YEH, Li-An [US/US]; (US) (For US Only).
CUNY, Gregory, D. [US/US]; (US) (For US Only)
Inventors: NICHOLSON, Melissa; (US).
WUCHERPFENNIG, Kai; (US).
STEIN, Ross, L.; (US).
YEH, Li-An; (US).
CUNY, Gregory, D.; (US)
Agent: FINCH, Stephen, R.; Wolf, Greenfield & Sacks, P.C., 600 Atlantic Avenue, Boston, MA 02210 (US)
Priority Data:
60/533,720 30.12.2003 US
Title (EN) THIOPHENE DERIVATIVES FOR UP-REGULATING HLA-DM ACTIVITY
(FR) DERIVES DE THIOPHENE DESTINES A LA REGULATION POSITIVE DE L'ACTIVITE HLA-DM
Abstract: front page image
(EN)Compounds of formula (I), compositions, methods and kits are provided. The compounds and compositions may be particularly useful for modulating immunological responses. Formula (I) wherein, R1is alkyl, aryl, or heterocyclyl; R2 is H, alkyl, aryl, heterocyclyl, OR3 or N(R3)2, R3 is H, alkyl, aryl, or heterocyclyl; R4 is H, CN, halogen, CF3, CO2R3, or C(O)N(R3)2; X is S, SO2, O, or NR3; and Y is S, O, or NR3.
(FR)L'invention concerne des composés de la formule (I), des compositions, des méthodes et des kits. Les composés et les compositions peuvent être particulièrement utiles pour moduler les réponses immunologiques. Dans ladite formule, R1 représente alkyle, aryle ou hétérocyclyle; R2 représente H, alkyle, aryle, hétérocyclyle, OR3 ou N(R3)2, R3 représente H, alkyle, aryle ou hétérocyclyle; R4 représente H, CN, halogène, CF3, CO2R3 ou C(O)N(R3)2; X représente S, SO2, O ou NR3; et Y représente S, O ou NR3.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)