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1. (WO2005066145) HETEROARYL-UREAS AND THEIR USE AS GLUCOKINASE ACTIVATORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/066145    International Application No.:    PCT/DK2005/000002
Publication Date: 21.07.2005 International Filing Date: 06.01.2005
IPC:
A61K 31/4168 (2006.01), A61K 31/427 (2006.01), A61K 31/433 (2006.01), C07D 213/75 (2006.01), C07D 233/88 (2006.01), C07D 241/20 (2006.01), C07D 261/14 (2006.01), C07D 271/08 (2006.01), C07D 277/46 (2006.01), C07D 277/48 (2006.01), C07D 277/56 (2006.01), C07D 277/60 (2006.01), C07D 277/82 (2006.01), C07D 285/08 (2006.01), C07D 285/135 (2006.01), C07D 417/04 (2006.01), C07D 417/06 (2006.01), C07D 417/12 (2006.01), C07D 417/14 (2006.01), C07D 513/04 (2006.01)
Applicants: NOVO NORDISK A/S [DK/DK]; Novo Allé, DK-2880 Bagsvaerd (DK) (For All Designated States Except US).
MURRAY, Anthony [GB/DK]; (DK) (For US Only).
LAU, Jesper [DK/DK]; (DK) (For US Only).
JEPPESEN, Lone [DK/DK]; (DK) (For US Only).
VEDSØ, Per [DK/DK]; (DK) (For US Only).
ANKERSEN, Michael [DK/DK]; (DK) (For US Only).
LUNDBECK, Jane, Marie [DK/DK]; (DK) (For US Only).
KRISTIANSEN, Marit [DK/DK]; (DK) (For US Only).
VALCARCE-LOPEZ, Maria Carmen [ES/SE]; (SE) (For US Only).
POLISETTI, Dharma, Rao [US/US]; (US) (For US Only).
SUBRAMANIAN, Govindan [IN/US]; (US) (For US Only).
ANDREWS, Robert, Carl [US/US]; (US) (For US Only).
CHRISTEN, Daniel, P. [US/US]; (US) (For US Only).
COOPER, Jeremy, T. [US/US]; (US) (For US Only).
SANTHOSH, Kalpathy, Chidambareswaran [US/US]; (US) (For US Only)
Inventors: MURRAY, Anthony; (DK).
LAU, Jesper; (DK).
JEPPESEN, Lone; (DK).
VEDSØ, Per; (DK).
ANKERSEN, Michael; (DK).
LUNDBECK, Jane, Marie; (DK).
KRISTIANSEN, Marit; (DK).
VALCARCE-LOPEZ, Maria Carmen; (SE).
POLISETTI, Dharma, Rao; (US).
SUBRAMANIAN, Govindan; (US).
ANDREWS, Robert, Carl; (US).
CHRISTEN, Daniel, P.; (US).
COOPER, Jeremy, T.; (US).
SANTHOSH, Kalpathy, Chidambareswaran; (US)
Common
Representative:
NOVO NORDISK A/S; Coporate Patents, Novo Allé, DK-2880 Bagsværd (DK)
Priority Data:
PA 2004 00013 06.01.2004 DK
PA 2004 01272 23.08.2004 DK
PA 2004 01897 07.12.2004 DK
Title (EN) HETEROARYL-UREAS AND THEIR USE AS GLUCOKINASE ACTIVATORS
(FR) HETEROARYL-UREES ET LEUR UTILISATION EN TANT QU'ACTIVATEURS DE GLUCOKINASE
Abstract: front page image
(EN)This invention relates to compounds that are of formula (I) wherein A is heteroaryl and R1 and R2 are both cyclic residues, that are activators of glucokinase and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial .
(FR)L'invention concerne des composés qui correspondent à la formule (I) dans laquelle A est un hétéroaryle et R1 et R2 sont tous deux des résidus cycliques, qui sont des activateurs de glucokinase et peuvent, de ce fait, s'utiliser pour gérer, traiter ou pour lutter contre des maladies ainsi qu'en tant que traitement auxiliaire lorsque l'augmentation des activités de glucokinase a un effet bénéfique.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)