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1. (WO2005065704) PREVENTIVE AND REMEDY FOR BONE DISEASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/065704    International Application No.:    PCT/JP2005/000092
Publication Date: 21.07.2005 International Filing Date: 07.01.2005
Chapter 2 Demand Filed:    15.02.2005    
IPC:
A61K 35/32 (2006.01), A61K 38/16 (2006.01), A61K 38/18 (2006.01), A61K 38/19 (2006.01), A61P 19/02 (2006.01), A61P 19/08 (2006.01), A61P 19/10 (2006.01), A61P 43/00 (2006.01), C12N 5/077 (2010.01)
Applicants: SAITAMA MEDICAL SCHOOL [JP/JP]; 38, Morohongo, Moroyamamachi, Iruma-gun, Saitama 3500495 (JP) (For All Designated States Except US).
SUDA, Tatsuo [JP/JP]; (JP) (For US Only).
HIGASHIO, Kanji [JP/JP]; (JP) (For US Only).
SERIZAWA, Hiroko [JP/JP]; (JP) (For US Only).
GOTO, Masaaki [JP/JP]; (JP) (For US Only).
KODAIRA, Kunihiko [JP/JP]; (JP) (For US Only).
TOMOYASU, Akihiro [JP/JP]; (JP) (For US Only)
Inventors: SUDA, Tatsuo; (JP).
HIGASHIO, Kanji; (JP).
SERIZAWA, Hiroko; (JP).
GOTO, Masaaki; (JP).
KODAIRA, Kunihiko; (JP).
TOMOYASU, Akihiro; (JP)
Agent: SHAMOTO, Ichio; YUASA AND HARA, Section 206, New Ohtemachi Bldg., 2-1, Ohtemachi 2-chome, Chiyoda-ku, Tokyo 1000004 (JP)
Priority Data:
2004-004083 09.01.2004 JP
Title (EN) PREVENTIVE AND REMEDY FOR BONE DISEASE
(FR) AGENT DE PRÉVENTION ET DE TRAITEMENT POUR MALADIES OSSEUSES
(JA) 骨疾患の予防および治療剤
Abstract: front page image
(EN)A method which comprises treating mesenchymal cells with platelet factor 4 in the presence of an osteogenesis inducer to thereby differentiate the cells into osteoblasts; a method which comprises treating mesenchymal cells with platelet factor 4 in the presence of an osteogenesis inducer to thereby differentiate the cells into osteoblasts and then further treating the osteoblasts with platelet factor 4 to thereby promote the differentiation and maturation thereof; and a preventive and remedy for a disease associated with a decrease in bone mass which comprises an osteogenesis inducer combined with platelet factor 4.
(FR)Méthode consistant à traiter des cellules mésenchymateuses avec du facteur plaquettaire 4 en présence d'un inducteur d'ostéogenèse pour différencier les cellules en ostéoblastes et ensuite à traiter les ostéoblastes avec du facteur plaquettaire 4 pour promouvoir la différenciation et la maturation desdits ostéoblastes. La présente invention concerne également un agent de prévention et de traitement pour une maladie associée à une réduction de la masse osseuse, qui contient un inducteur d'ostéogenèse combiné à du facteur plaquettaire 4.
(JA) 骨形成誘導因子の存在下に、間葉系細胞に血小板第4因子を作用させて、該細胞を骨芽細胞に分化させる方法;骨形成誘導因子の存在下に、間葉系細胞に血小板第4因子を作用させて該細胞を骨芽細胞に分化させ、さらに血小板第4因子を作用させて該骨芽細胞の分化・成熟を促進する方法;及び骨量減少を伴う骨疾患の予防および治療剤であって、該治療剤が、骨形成誘導因子および血小板第4因子との組み合わせからなる前記骨疾患の予防および治療剤。                                                                                 
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)