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1. (WO2005065683) TRIAZOLE, OXADIAZOLE AND THIADIAZOLE DERIVATIVE AS PPAR MODULATORS FOR THE TREATMENT OF DIABETES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/065683    International Application No.:    PCT/US2004/039775
Publication Date: 21.07.2005 International Filing Date: 21.12.2004
Chapter 2 Demand Filed:    11.10.2005    
IPC:
A61K 31/4196 (2006.01), A61K 31/4245 (2006.01), A61K 31/433 (2006.01), C07D 249/08 (2006.01), C07D 271/107 (2006.01), C07D 285/12 (2006.01)
Applicants: ELI LILLY AND COMPANY [US/US]; Lilly Corporate Center, Indianapolis, IN 46285 (US) (For All Designated States Except US).
MANTLO, Nathan, Bryan [US/US]; (US) (For US Only).
NAVARRO, Antonio [ES/US]; (US) (For US Only).
SAEED, Ashraf [US/US]; (US) (For US Only).
GERNERT, Douglas, Linn [US/US]; (US) (For US Only).
MA, Tianwei [CN/US]; (US) (For US Only).
PFEIFER, Lance, Allen [US/US]; (US) (For US Only)
Inventors: MANTLO, Nathan, Bryan; (US).
NAVARRO, Antonio; (US).
SAEED, Ashraf; (US).
GERNERT, Douglas, Linn; (US).
MA, Tianwei; (US).
PFEIFER, Lance, Allen; (US)
Agent: VORNDRAN-JONES, MaCharri; P.O. Box 6288, Indianapolis, IN 46206-6288 (US)
Priority Data:
60/532,320 22.12.2003 US
60/586,563 09.07.2004 US
04380159.6 21.07.2004 EP
04380158.8 21.07.2004 EP
Title (EN) TRIAZOLE, OXADIAZOLE AND THIADIAZOLE DERIVATIVE AS PPAR MODULATORS FOR THE TREATMENT OF DIABETES
(FR) DERIVE DE TRIAZOLE, OXADIAZOLE ET THIADIAZOLE EN TANT QUE MODULATEURS DE PPAR POUR LE TRAITEMENT DU DIABETE
Abstract: front page image
(EN)The present invention is directed to compounds represented by the following structural formula, Formula (I): wherein: (a) X is selected from the group consisting of a single bond, O, S, S(O)2 and N; (b) U is an aliphatic linker; (c) Y is selected from the group consisting of O, C, S, NH and a single bond; (d) W is N, O or S; (e) E is C(R3)(R4)A or A and wherein; (f) A is selected from the group consisting of carboxyl, tetrazole, C1-C6 alkylnitrile, carboxamide, sulfonamide and acylsufonamide. The other substituents are defined in the claims; the compounds are modulators of peroxisome proleferator activated receptors (PPARs) and are useful for the treatment of diabetes and other metabolic disorders.
(FR)La présente invention a trait à des composés de formule structurelle (I), dans laquelle : (a) X est choisi parmi le groupe constitué d'une liaison simple, O, S, S(O)2 et N ; (b) U est une liaison aliphatique ; (c) Y est choisi parmi le groupe constitué de O, C, S, NH et une liaison simple ; (d) W est N, O ou S ; (e) E est C(R3)(R4)A ou A et dans laquelle (f) A est choisi parmi le groupe constitué de carboxyle, tétrazole, alkylnitrile en C1 C6, carboxamide, sulfonamide et acylsulfonamide. Les autres substituants sont tels que définis dans les revendications ; les composés sont des modulateurs des récepteurs activés de la prolifération des peroxisomes (PPAR) et sont utiles pour le traitement du diabète et d'autres troubles métaboliques.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)