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Machine translation
1. (WO2005065284) TISSUE ABLATION WITH IRREVERSIBLE ELECTROPORATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/065284    International Application No.:    PCT/US2004/043477
Publication Date: 21.07.2005 International Filing Date: 21.12.2004
IPC:
A61B 18/18 (2006.01)
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street, 12th Floor, Oakland, California 94607-5200 (US) (For All Designated States Except US).
DAVALOS, Rafael [US/US]; (US) (For US Only).
RUBINSKY, Boris [US/US]; (US) (For US Only)
Inventors: DAVALOS, Rafael; (US).
RUBINSKY, Boris; (US)
Agent: BOZICEVIC, Karl; BOZICEVIC, FIELD & FRANCIS LLP, 1900 University Avenue, Suite 200, East Palo Alto, California 94303 (US)
Priority Data:
60/532,588 24.12.2003 US
Title (EN) TISSUE ABLATION WITH IRREVERSIBLE ELECTROPORATION
(FR) ABLATION DE TISSU AVEC ELECTROPORATION IRREVERSIBLE
Abstract: front page image
(EN)A new method for the ablation of undesirable tissue such as cells of a cancerous or non-cancerous tumor is disclosed. It involves the placement of electrodes into or near the vicinity of the undesirable tissue through the application of electrical pulses causing irreversible electroporation of the cells throughout the entire area of the undesirable tissue. The electric pulses irreversibly permeate the cell membranes, thereby invoking cell death. The irreversibly permeabilized cells are left in situ and are removed by the body immune system. The amount of tissue ablation achievable through the use of irreversible electroporation without inducing thermal damage is considerable.
(FR)L'invention concerne une nouvelle méthode destinée à l'ablation d'un tissu indésirable, et notamment de cellules d'une tumeur cancéreuse ou non cancéreuse. Cette méthode consiste à placer des électrodes à l'intérieur ou au voisinage du tissu indésirable en vue de l'application d'impulsions électriques causant une électroporation irréversible des cellules dans toute la zone du tissu indésirable. Les impulsions électriques perméabilisent de façon irréversible les membranes cellulaires, ce qui provoque la mort des cellules. Les cellules perméabilisées de façon irréversible sont laissées in situ et éliminées par le système immunitaire du corps. La quantité de tissu que l'on peut ablater par électroporation irréversible sans lésion thermique est très importante.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)