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1. (WO2005065195) PHENYLAMIDE AND PYRIDYLAMIDE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/065195    International Application No.:    PCT/US2004/042173
Publication Date: 21.07.2005 International Filing Date: 15.12.2004
IPC:
C07C 237/00 (2006.01), C07D 213/02 (2006.01), A61K 31/18 (2006.01), A61K 31/44 (2006.01)
Applicants: MERCK & CO., INC. [US/US]; 126 East Lincoln Avenue, Rahway, New Jersey 07065-0907 (US) (For All Designated States Except US).
BARROW, James, C. [US/US]; (US) (For US Only).
COBURN, Craig, A. [US/US]; (US) (For US Only).
NANTERMET, Philippe, G. [FR/US]; (US) (For US Only).
SELNICK, Harold, G. [US/US]; (US) (For US Only).
STACHEL, Shawn, J. [US/US]; (US) (For US Only).
STANTON, Matthew, G. [US/US]; (US) (For US Only).
STAUFFER, Shaun, R. [US/US]; (US) (For US Only).
ZHUANG, Linghang [CN/US]; (US) (For US Only).
DAVIS, Jennifer, R. [US/US]; (US) (For US Only)
Inventors: BARROW, James, C.; (US).
COBURN, Craig, A.; (US).
NANTERMET, Philippe, G.; (US).
SELNICK, Harold, G.; (US).
STACHEL, Shawn, J.; (US).
STANTON, Matthew, G.; (US).
STAUFFER, Shaun, R.; (US).
ZHUANG, Linghang; (US).
DAVIS, Jennifer, R.; (US)
Common
Representative:
MERCK & CO., INC.; 126 East Lincoln Avenue, Rahway, New Jersey 07065-0907 (US)
Priority Data:
60/531,423 19.12.2003 US
Title (EN) PHENYLAMIDE AND PYRIDYLAMIDE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
(FR) INHIBITEURS DE PHENYLAMIDE ET DE PYRIDYLAMIDE DE LA BETA-SECRETASE, TRAITANT LA MALADIE D'ALZHEIMER
Abstract: front page image
(EN)The present invention is directed to phenylamide and pyridylamide derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
(FR)L'invention porte sur des composés dérivant de la phénylamide et de la pyridylamide, inhibiteurs de la bêta-secrétase, et s'avérant utiles dans le traitement de maladies telles que celle d'Alzheimer où la bêta-secrétase est impliquée. L'invention porte également sur des préparations pharmaceutiques comprenant ces composés et leur utilisation, et sur des préparations traitant de telles maladies.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)