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1. (WO2005065183) MITOTIC KINESIN INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/065183    International Application No.:    PCT/US2004/042070
Publication Date: 21.07.2005 International Filing Date: 15.12.2004
IPC:
A61K 31/505 (2006.01), C07D 239/91 (2006.01)
Applicants: MERCK & CO., INC. [US/US]; 126 East Lincoln Avenue, Rahway, NJ 07065-0907 (US) (For All Designated States Except US).
ARRINGTON, Kenneth, L. [US/US]; (US) (For US Only).
FRALEY, Mark, E. [US/US]; (US) (For US Only).
HARTMAN, George, D. [US/US]; (US) (For US Only)
Inventors: ARRINGTON, Kenneth, L.; (US).
FRALEY, Mark, E.; (US).
HARTMAN, George, D.; (US)
Common
Representative:
MERCK & CO., INC.; 126 East Lincoln Avenue, Rahway, NJ 07065-0907 (US)
Priority Data:
60/531,372 19.12.2003 US
Title (EN) MITOTIC KINESIN INHIBITORS
(FR) INHIBITEURS MITOTIQUES DE LA KINESINE
Abstract: front page image
(EN)The present invention relates to 2,3-diarylquinazolinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
(FR)L'invention porte sur des composés de 2,3-diarylquinazolinone s'avérant utiles pour traiter les maladies à prolifération cellulaire et les troubles associés à l'activité de la kinésine KSP, et inhiber la kinésine KSP. L'invention porte également sur des compositions comprenant lesdits composés, et sur des méthodes de traitement des cancers chez les mammifères les utilisant.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)