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1. (WO2005064343) BIOMARKERS FOR SENSITIVITY OF PROLIFERATIVE DISEASES TO MTOR INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/064343    International Application No.:    PCT/EP2004/014549
Publication Date: 14.07.2005 International Filing Date: 21.12.2004
IPC:
G01N 33/574 (2006.01), G01N 33/68 (2006.01)
Applicants: NOVARTIS AG [CH/CH]; Lichtstrasse 35, CH-4056 Basel (CH) (AE, AG, AL, AM, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NA, NE, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, YU, ZA, ZM, ZW only).
NOVARTIS PHARMA GMBH [AT/AT]; Brunner Strasse 59, A-1230 Vienna (AT) (AT only).
BOULAY, Anne [FR/FR]; (FR) (For US Only).
LANE, Heidi [CH/CH]; (CH) (For US Only).
MAIRA, Sauveur-Michel [FR/FR]; (FR) (For US Only).
O'REILLY, Terence [CA/CH]; (CH) (For US Only)
Inventors: BOULAY, Anne; (FR).
LANE, Heidi; (CH).
MAIRA, Sauveur-Michel; (FR).
O'REILLY, Terence; (CH)
Agent: GRUBB, Philip; Novartis AG, Corporate Intellectual Property, CH-4002 Basel (CH)
Priority Data:
60/531,700 22.12.2003 US
Title (EN) BIOMARKERS FOR SENSITIVITY OF PROLIFERATIVE DISEASES TO MTOR INHIBITORS
(FR) BIOMARQUEURS POUR LA SENSIBILITE DE MALADIES PROLIFERANTES AUX INHIBITEURS MTOR
Abstract: front page image
(EN)Disclosed is a method for determining the sensitivity of a proliferate disease in a subject to treatment with an mTOR inhibitor, comprising determining the level of expression and/or phosphorylation state of S6 in a sample derived from the subject, as well as related methods of treatment and uses.
(FR)La présente invention à un procédé de détermination de la sensibilité d'une maladie proliférante chez un sujet à un traitement avec un inhibiteur mTOR, comprenant la détermination du niveau de l'état d'expression et/ou de phosphorylation de S26 dans un échantillon dérivé du sujet, ainsi qu'à des procédés de traitement et d'utilisation.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)