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1. (WO2005064341) METHODS FOR THE IN VITRO DIAGNOSIS AND IN VITRO PROGNOSIS OF DEMYELINATING DISEASES, AND FOR THE DEVELOPMENT OF DRUGS AGAINST DEMYELINATING DISEASES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/064341    International Application No.:    PCT/EP2004/014814
Publication Date: 14.07.2005 International Filing Date: 28.12.2004
IPC:
C12N 9/16 (2006.01), G01N 33/573 (2006.01)
Applicants: PROGENIKA BIOPHARMA, S.A. [ES/ES]; Parque Tecnológico de Zamudio, Ibaizabal Bidea - Edificio 801 - A 2ª planta, E-48160 DERIO - Vizcaya (ES) (For All Designated States Except US).
UNIVERSIDAD DEL PAÍS VASCO [ES/ES]; Rectorado, Barrio Sarriena, s/n, 48940 Leioa-Vizcaya (ES) (For All Designated States Except US).
ARIZ LÓPEZ DE CASTRO, Usúe [ES/ES]; (ES) (For US Only).
OSABA ORTIZ DE MENDIBIL, Lourdes [ES/ES]; (ES) (For US Only).
JUNQUERA SÁNCHEZ-VALLEJO, Corina [ES/ES]; (ES) (For US Only).
OCHOA GARAY, Jorge [ES/ES]; (ES) (For US Only).
ESCUDERO GARCÍA DE GALDEANO, Pedro [ES/ES]; (ES) (For US Only).
SANTA CRUZ, Simon [ES/ES]; (ES) (For US Only).
SIMÓN BUELA, Laureano [ES/ES]; (ES) (For US Only).
MARTÍNEZ MARTÍNEZ, Antonio [ES/ES]; (ES) (For US Only).
MATUTE ALMAU, Carlos [ES/ES]; (ES) (For US Only).
DOMERCQ GARCÍA, María [ES/ES]; (ES) (For US Only).
ALBERDI ALFONSO, Elena [ES/ES]; (ES) (For US Only).
SÁNCHEZ GÓMEZ, María Victoria [ES/ES]; (ES) (For US Only).
VALLEJO ILLARRAMENDI, Ainara [ES/ES]; (ES) (For US Only).
IBARRETXE BILBAO, Gaskon [ES/ES]; (ES) (For US Only).
ETXEBARRIA GALNARES, Estibaliz [ES/ES]; (ES) (For US Only)
Inventors: ARIZ LÓPEZ DE CASTRO, Usúe; (ES).
OSABA ORTIZ DE MENDIBIL, Lourdes; (ES).
JUNQUERA SÁNCHEZ-VALLEJO, Corina; (ES).
OCHOA GARAY, Jorge; (ES).
ESCUDERO GARCÍA DE GALDEANO, Pedro; (ES).
SANTA CRUZ, Simon; (ES).
SIMÓN BUELA, Laureano; (ES).
MARTÍNEZ MARTÍNEZ, Antonio; (ES).
MATUTE ALMAU, Carlos; (ES).
DOMERCQ GARCÍA, María; (ES).
ALBERDI ALFONSO, Elena; (ES).
SÁNCHEZ GÓMEZ, María Victoria; (ES).
VALLEJO ILLARRAMENDI, Ainara; (ES).
IBARRETXE BILBAO, Gaskon; (ES).
ETXEBARRIA GALNARES, Estibaliz; (ES)
Agent: ARIAS SANZ, Juan; ABG Patentes, S.L., Orense, 68, 7th floor, E-28020 Madrid (ES)
Priority Data:
03380310.7 30.12.2003 EP
Title (EN) METHODS FOR THE IN VITRO DIAGNOSIS AND IN VITRO PROGNOSIS OF DEMYELINATING DISEASES, AND FOR THE DEVELOPMENT OF DRUGS AGAINST DEMYELINATING DISEASES
(FR) METHODES DE DIAGNOSTIC IN VITRO ET DE PRONOSTIC IN VITRO DE MALADIES DE DEMYELINISATION, ET METHODES DE MISE AU POINT DE MEDICAMENTS CONTRE DES MALADIES DE DEMYELINISATION
Abstract: front page image
(EN)The present invention refers to an in vitro method for detecting the presence of demyelinating diseases in an individual, for determining the stage or severity of said diseases in the individual, or for monitoring the effect of the therapy administered to an individual suffering said diseases; to the search, identification, development and evaluation of efficacy of compounds for therapy of said diseases for the purpose of developing new drugs; as well as to agents inhibiting DUSP6 protein expression and/or activity, and/or the effects of this expression. The methods and agents of the invention are preferably applied to multiple sclerosis.
(FR)La présente invention concerne une méthode in vitro, qui permet de détecter la présence de maladies de démyélinisation chez un individu, en vue de déterminer l'évolution ou la gravité desdites maladies chez l'individu, ou de contrôler l'effet du traitement administré à un individu atteint d'une telle maladie. L'invention concerne également le dépistage, l'identification, l'élaboration et l'évaluation de l'efficacité de composés destinés au traitement desdites maladies, dans le but de mettre au point de nouveaux médicaments. L'invention concerne en outre des agents qui inhibent l'expression et/ou l'activité de la protéine DUSP6, et/ou les effets de cette expression. Les méthodes et agents de l'invention s'appliquent, de préférence, à la sclérose en plaques.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)