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1. WO2005064307 - METHOD OF ASSESSING RHEUMATOID ARTHRITIS BY MEASURING ANTI-CCP AND INTERLEUKIN 6

Publication Number WO/2005/064307
Publication Date 14.07.2005
International Application No. PCT/EP2004/014527
International Filing Date 21.12.2004
Chapter 2 Demand Filed 02.08.2005
IPC
G01N 33/564 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
564for pre-existing immune complex or autoimmune disease
G01N 33/68 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
CPC
G01N 33/564
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
564for pre-existing immune complex or autoimmune disease ; , i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
G01N 33/6869
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
6863Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
6869Interleukin
Applicants
  • ROCHE DIAGNOSTICS GMBH [DE]/[DE] (DE)
  • F.HOFFMANN-LA ROCHE AG [CH]/[CH] (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DK, DM, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NA, NE, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, YU, ZA, ZM, ZW)
  • WILD, Norbert [DE]/[DE] (UsOnly)
  • KARL, Johann [DE]/[DE] (UsOnly)
  • GRUNERT, Veit, Peter [DE]/[DE] (UsOnly)
  • ZOLG, Werner [DE]/[DE] (UsOnly)
Inventors
  • WILD, Norbert
  • KARL, Johann
  • GRUNERT, Veit, Peter
  • ZOLG, Werner
Common Representative
  • ROCHE DIAGNOSTICS GMBH
Priority Data
03029658.623.12.2003EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHOD OF ASSESSING RHEUMATOID ARTHRITIS BY MEASURING ANTI-CCP AND INTERLEUKIN 6
(FR) METHODE DE DIAGNOSTIC DE LA POLYARTHRITE RHUMATOIDE, CONSISTANT A MESURER LA CONCENTRATION D'ANTI-CCP ET D'INTERLEUKINE 6
Abstract
(EN)
The present invention relates to a method aiding in the assessment of rheumatoid arthritis. The method especially is used in assessing the absence or presence of rheumatoid arthritis in vitro. The method is for example practiced by analyzing biochemical markers, comprising measuring in a sample the concentration of anti-CCP and interleukin 6 and correlating the concentrations determined to the absence or presence of rheumatoid arthritis. To further improve the assessment of RA in a method of this invention the level of one or more additional marker may be determined together with anti-CCP and interleukin 6 and be correlated to the absence or presence of RA. The invention also relates to the use of a marker panel comprising anti-CCP and interleukin 6 in the diagnosis of rheumatoid arthritis and it teaches a kit for performing the method of the invention.
(FR)
La présente invention concerne une méthode de diagnostic de la polyarthrite rhumatoïde. Cette méthode est tout particulièrement utilisée pour détecter l'absence ou la présence de la polyarthrite rhumatoïde in vitro. Cette méthode est mise en oeuvre, par exemple, par analyse de marqueurs biochimiques, et consiste à mesurer dans un échantillon la concentration d'anti-CCP et d'interleukine 6 et à associer les valeurs obtenues à l'absence ou à la présence de l'arthrite rhumatoïde. Pour améliorer davantage cette méthode de diagnostic, on peut déterminer la concentration d'un ou plusieurs marqueurs supplémentaires avec les anti-CCP et l'interleukine 6 et associer les valeurs obtenues à l'absence ou à la présence de l'arthrite rhumatoïde. L'invention concerne également l'utilisation d'un ensemble de marqueurs comprenant l'anti-CCP et l'interleukine 6 pour le diagnostic de l'arthrite rhumatoïde, ainsi qu'une trousse destinée à la mise en oeuvre de la méthode décrite ci-dessus.
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