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1. WO2005063801 - METHOD FOR DECREASING THE CONTACT BETWEEN HEPTA-REPEAT REGION S OF THE CORONA-VIRUS SPIKE PROTEINS AND USE THEREOF

Publication Number WO/2005/063801
Publication Date 14.07.2005
International Application No. PCT/NL2004/000924
International Filing Date 30.12.2004
IPC
A61K 39/215 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
215Coronaviridae, e.g. avian infectious bronchitis virus
C07K 14/165 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
165Coronaviridae, e.g. avian infectious bronchitis virus
C07K 16/10 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08against material from viruses
10from RNA viruses
CPC
A61K 2039/525
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
525Virus
A61K 2039/5254
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
525Virus
5254avirulent or attenuated
A61K 2039/5256
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
525Virus
5256expressing foreign proteins
A61K 2039/5258
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
525Virus
5258Virus-like particles
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 39/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
Applicants
  • Universiteit Utrecht Holding B.V. [NL]/[NL] (AllExceptUS)
  • Universiteit Utrecht [NL]/[NL] (AllExceptUS)
  • ROTTIER, Petrus, Josephus, Marie [NL]/[NL] (UsOnly)
  • BOSCH, Berend, Jan [NL]/[NL] (UsOnly)
Inventors
  • ROTTIER, Petrus, Josephus, Marie
  • BOSCH, Berend, Jan
Agents
  • WINCKELS, J.H.F.
Priority Data
10/750,41130.12.2003US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHOD FOR DECREASING THE CONTACT BETWEEN HEPTA-REPEAT REGION S OF THE CORONA-VIRUS SPIKE PROTEINS AND USE THEREOF
(FR) PARTICULES DU TYPE CORONAVIRUS COMPRENANT DES GENOMES A DELETIONS FONCTIONNELLES
Abstract
(EN) The invention relates to the field of coronaviruses and diagnosis, therapeutic use and vaccines derived thereof. Methods are shown for at least in part inhibiting anti-parallel coiled coil formation of a coronavirus spike protein comprising decreasing the contact between heptad repeat regions of said protein. The invention provides a peptide comprising a heptad repeat region of a corona viral spike protein and/or a functional fragment and/or an derivative thereof. The invention also provides antibodies and compounds inhibiting corona viral infection of cells, and/or cell-to-cell fusion. The invention also discloses heptad repeat regions and a fusion peptide of SARS-CoV.
(FR) L'invention concerne le domaine des coronavirus, leur utilisation diagnostique et thérapeutique et des vaccins dérivés des coronavirus; des méthodes destinées à inhiber au moins partiellement une formation bispiralée antiparallèle d'une protéine d'enrichissement coronavirale et à réduire le contact entre des régions de répétition d'heptades de cette protéine; un peptide comprenant une région de répétition d'heptades d'une protéine d'enrichissement coronavirale et/ou un fragment fonctionnel et/ou un dérivé de ladite protéine; des anticorps et des composés qui inhibent les infections coronavirales de cellules et/ou fusion cellule à cellule; des régions de répétition d'heptades et un peptide de fusion du SARS-CoV.
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