WO2005063801 METHOD FOR DECREASING THE CONTACT BETWEEN HEPTA-REPEAT REGION S OF THE CORONA-VIRUS SPIKE PROTEINS AND USE THEREOF

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Publication Number WO/2005/063801

Publication Date 14.07.2005

International Application No. PCT/NL2004/000924

International Filing Date 30.12.2004

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CPC

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Applicants

Universiteit Utrecht Holding B.V. [NL]/[NL] (AllExceptUS)
Universiteit Utrecht [NL]/[NL] (AllExceptUS)
ROTTIER, Petrus, Josephus, Marie [NL]/[NL] (UsOnly)
BOSCH, Berend, Jan [NL]/[NL] (UsOnly)

Inventors

ROTTIER, Petrus, Josephus, Marie
BOSCH, Berend, Jan

Agents

WINCKELS, J.H.F.

Priority Data

10/750,411

30.12.2003

Publication Language English (en)

Filing Language English (EN)

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Title

(EN) METHOD FOR DECREASING THE CONTACT BETWEEN HEPTA-REPEAT REGION S OF THE CORONA-VIRUS SPIKE PROTEINS AND USE THEREOF

(FR) PARTICULES DU TYPE CORONAVIRUS COMPRENANT DES GENOMES A DELETIONS FONCTIONNELLES

Abstract

(EN) The invention relates to the field of coronaviruses and diagnosis, therapeutic use and vaccines derived thereof. Methods are shown for at least in part inhibiting anti-parallel coiled coil formation of a coronavirus spike protein comprising decreasing the contact between heptad repeat regions of said protein. The invention provides a peptide comprising a heptad repeat region of a corona viral spike protein and/or a functional fragment and/or an derivative thereof. The invention also provides antibodies and compounds inhibiting corona viral infection of cells, and/or cell-to-cell fusion. The invention also discloses heptad repeat regions and a fusion peptide of SARS-CoV.

(FR) L'invention concerne le domaine des coronavirus, leur utilisation diagnostique et thérapeutique et des vaccins dérivés des coronavirus; des méthodes destinées à inhiber au moins partiellement une formation bispiralée antiparallèle d'une protéine d'enrichissement coronavirale et à réduire le contact entre des régions de répétition d'heptades de cette protéine; un peptide comprenant une région de répétition d'heptades d'une protéine d'enrichissement coronavirale et/ou un fragment fonctionnel et/ou un dérivé de ladite protéine; des anticorps et des composés qui inhibent les infections coronavirales de cellules et/ou fusion cellule à cellule; des régions de répétition d'heptades et un peptide de fusion du SARS-CoV.

Latest bibliographic data on file with the International Bureau

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39	Medicinal preparations containing antigens or antibodies
12	Viral antigens
215	Coronaviridae, e.g. avian infectious bronchitis virus

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
14	Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005	from viruses
08	RNA viruses
165	Coronaviridae, e.g. avian infectious bronchitis virus

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
16	Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08	against material from viruses
10	from RNA viruses

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39	Medicinal preparations containing antigens or antibodies
12	Viral antigens
215	Coronaviridae, e.g. avian infectious bronchitis virus

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
14	Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005	from viruses
08	RNA viruses
165	Coronaviridae, e.g. avian infectious bronchitis virus

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1. WO2005063801 - METHOD FOR DECREASING THE CONTACT BETWEEN HEPTA-REPEAT REGION S OF THE CORONA-VIRUS SPIKE PROTEINS AND USE THEREOF

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1	Drugs for disorders of the alimentary tract or the digestive system
16	for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N	MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15	Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09	Recombinant DNA-technology
63	Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79	Vectors or expression systems specially adapted for eukaryotic hosts
85	for animal cells
86	Viral vectors

G	PHYSICS
01	MEASURING; TESTING
N	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333	Assays involving biological materials from specific organisms or of a specific nature
005	from viruses
08	RNA viruses
165	Coronaviridae, e.g. avian infectious bronchitis virus