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1. (WO2005063767) INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, AND 1,2-BENZISOTHIAZOLES, AND PREPARATION AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/063767    International Application No.:    PCT/US2004/042852
Publication Date: 14.07.2005 International Filing Date: 22.12.2004
IPC:
C07D 487/18 (2006.01)
Applicants: MEMORY PHARMACEUTICALS CORPORATION [US/US]; 100 Philips Parkway, Montvale, NJ 07645 (US) (For All Designated States Except US).
XIE, Wenge [US/US]; (US) (For US Only).
HERBERT, Brian [US/US]; (US) (For US Only).
MA. Jianguo [CA/US]; (US) (For US Only).
NGUYEN, Truc, Minh [US/US]; (US) (For US Only).
SCHUMACHER, Richard, A. [US/US]; (US) (For US Only).
GAUSS, Carla-Maria [US/US]; (US) (For US Only).
TEHIM, Ashok [CA/US]; (US) (For US Only)
Inventors: XIE, Wenge; (US).
HERBERT, Brian; (US).
MA. Jianguo; (US).
NGUYEN, Truc, Minh; (US).
SCHUMACHER, Richard, A.; (US).
GAUSS, Carla-Maria; (US).
TEHIM, Ashok; (US)
Agent: HEANEY, Brion, P.; Millen, White, Zelano & Branigan, P.C., Arlington Courthouse Plaza 1, 2200 Clarendon Boulevard, Suite 1400, Arlington, VA 22201 (US)
Priority Data:
60/530,891 22.12.2003 US
60/606,897 03.09.2004 US
Title (EN) INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, AND 1,2-BENZISOTHIAZOLES, AND PREPARATION AND USES THEREOF
(FR) INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, ET 1,2-BENZISOTHIAZOLES, ET LEUR PREPARATION ET UTILISATION
Abstract: front page image
(EN)The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds for example, indoles, 1H-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, which act as ligands for the &agr;7 nAChR subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.
(FR)La présente invention concerne généralement le domaine des ligands pour les récepteurs d'acétylcholine nicotinique (nAChR), de l'activation de nAChRs, et du traitement des états pathologiques associés aux récepteurs d'acétylcholine nicotinique défectueux ou défaillants, notamment dans le cerveau. En outre, l'invention concerne de nouveaux composés, par exemple, des indoles, 1H-indazoles, 1,2-benzisoxazoles et 1,2-benzisothiazoles, qui fonctionnent en tant que ligands pour le sous-type ?7 nAChR, des procédés de préparation de ces composés, des compositions contenant ces composés et des procédés d'utilisation correspondants.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)