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1. (WO2005063737) AMIDOPYRAZOLE DERIVATIVE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/063737    International Application No.:    PCT/JP2004/019582
Publication Date: 14.07.2005 International Filing Date: 27.12.2004
IPC:
A61K 31/4439 (2006.01), A61K 31/444 (2006.01), A61K 31/497 (2006.01), A61K 31/501 (2006.01), A61P 7/02 (2006.01), A61P 9/10 (2006.01), C07D 401/04 (2006.01), C07D 401/14 (2006.01), C07D 405/14 (2006.01), C07D 417/14 (2006.01)
Applicants: DAIICHI PHARMACEUTICAL CO., LTD. [JP/JP]; 14-10, Nihonbashi 3-chome Chuo-ku, Tokyo 1038234 (JP) (For All Designated States Except US).
KANAYA, Naoaki [JP/JP]; (JP) (For US Only).
ISHIYAMA, Takashi [JP/JP]; (JP) (For US Only).
MUTO, Ryo [JP/JP]; (JP) (For US Only).
OCHIAI, Yuichi [JP/JP]; (JP) (For US Only).
WATANABE, Toshiyuki [JP/JP]; (JP) (For US Only).
SHIMA, Noriko [JP/JP]; (JP) (For US Only)
Inventors: KANAYA, Naoaki; (JP).
ISHIYAMA, Takashi; (JP).
MUTO, Ryo; (JP).
OCHIAI, Yuichi; (JP).
WATANABE, Toshiyuki; (JP).
SHIMA, Noriko; (JP)
Agent: THE PATENT CORPORATE BODY ARUGA PATENT OFFICE; Kyodo Bldg. 3-6, Nihonbashiningyocho 1-chome Chuo-ku, Tokyo 1030013 (JP)
Priority Data:
2003-434726 26.12.2003 JP
2004-012154 20.01.2004 JP
2004-321117 04.11.2004 JP
Title (EN) AMIDOPYRAZOLE DERIVATIVE
(FR) DÉRIVÉ D'AMIDOPYRAZOLE
(JA) アミドピラゾール誘導体
Abstract: front page image
(EN)A platelet aggregation inhibitor not inhibiting COX-1 and COX-2, comprised of a compound of the general formula: (I) (wherein each of Ar1 and Ar2 independently represents a 5- or 6-membered aromatic heterocycle optionally having one to three substituents, or phenyl optionally having one to three substituents; R1 is a lower acyl, carboxyl, a lower alkoxycarbonyl, a lower alkyl optionally having one or two substituents, carbamoyl optionally having one or two substituents, oxamoyl optionally having one or two substituents, amino optionally having one or two substituents, a 4- to 7-membered alicyclic heterocycle optionally having one or two substituents, phenyl optionally having one to three substituents, or a 5- or 6-membered aromatic heterocycle optionally having one to three substituents; and R2 is hydrogen, a halogeno, etc.).
(FR)L'invention porte sur un inhibiteur de l'agrégation des plaquettes qui n'inhibe ni COX-1 ni COX-2, et qui comprend un composé de la formule générale (1) : (dans laquelle chacun de Ar1 et Ar2 représente indépendamment un hétérocycle aromatique à 5 ou 6 chaînons comprenant facultativement de un à trois substituants, ou un phényle comprenant facultativement de un à trois substituants ; R1 est un acyle inférieur, un carboxyle, un alcoxycarbonyle inférieur, un alkyle inférieur comprenant facultativement de un à deux substituants, un carbomoyle comprenant facultativement de un à deux substituants, un oxamoyle comprenant facultativement de un à deux substituants, un amino comprenant facultativement de un à deux substituants, un hétérocycle alicyclique de 4 à 7 chaînons comprenant facultativement de un à deux substituants, un phényle comprenant facultativement de un à trois substituants, ou un hétérocycle aromatique à 5 ou 6 chaînons comprenant facultativement de un à trois substituants ; et R2 est un hydrogène, un halogéno, etc.).
(JA)not available
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)