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Machine translation
1. (WO2005063693) IMPROVED PROCESS FOR THE PREPARATION OF ENTACAPONE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/063693    International Application No.:    PCT/IN2003/000401
Publication Date: 14.07.2005 International Filing Date: 29.12.2003
IPC:
C07C 253/30 (2006.01), C07C 255/41 (2006.01)
Applicants: SUVEN LIFE SCIENCES LTD [IN/IN]; SDE SERENE CHAMBERS, ROAD # 7 , BANJARA HILLS, 500034 HYDERABAD (IN) (For All Designated States Except US).
VEERA REDDY, Arava [IN/IN]; (IN) (For US Only).
RAJENDIRAN, Chinnapillai [IN/IN]; (IN) (For US Only).
MD, QADEERUDDIN, md, samiuddin [IN/IN]; (IN) (For US Only).
JASTI, Venkateswarlu [US/IN]; (IN) (For US Only)
Inventors: VEERA REDDY, Arava; (IN).
RAJENDIRAN, Chinnapillai; (IN).
MD, QADEERUDDIN, md, samiuddin; (IN).
JASTI, Venkateswarlu; (IN)
Agent: SUBRAMANIAM, Hariharan; Subramaniam, Nataraj & Associates, E-556, Greater Kailash II, New Delhi-110 048 (IN)
Priority Data:
Title (EN) IMPROVED PROCESS FOR THE PREPARATION OF ENTACAPONE
(FR) PROCEDE AMELIORE DE PREPARATION DE L'ENTACAPONE
Abstract: front page image
(EN)The invention disclosed in this application relates to an improved process for the preparation of the Entacapone which comprises. (i)reacting 3-alkoxy- 4-hydroxy-5-nitrobenzadehyde with N,N-diethylaminocyanoactamide in the presence of mild acid catalyst and a solvent at a temperature in the range of 50-115 °C, to get the 3-O-alkylated (methyl or ethyl) Entacapone and treating with acid catalysts in the presence of organic base and solvents at temperature in the range of 20-60 °C to get Entacapone.
(FR)cette invention concerne un procédé amélioré permettant de préparer de l'entacapone, lequel procédé consiste (i) à faire réagir 3-alkoxy-4-hydroxy-5-nitrobenzadéhyde avec N,N-diéthylaminocyanoactamide en présence d'un catalyseur acide doux et d'un solvant à une température comprise entre 50 et 115 °C, pour obtenir l'entacapone 3-O-alkylaté (méthyl ou éthyl), puis à traiter avec des catalyseurs acides doux en présence d'une base organique et de solvants à une température comprise entre 20 et 60 °C pour obtenir l'entacapone.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)