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1. WO2005063368 - METHOD FOR MIXING FLUID STREAMS, MICROFLUIDIC MIXER AND MICROFLUIDIC CHIP UTILIZING SAME

Publication Number WO/2005/063368
Publication Date 14.07.2005
International Application No. PCT/US2004/043152
International Filing Date 22.12.2004
IPC
B01F 5/06 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
5Flow mixers; Mixers for falling materials, e.g. solid particles
06Mixers in which the components are pressed together through slits, orifices, or screens
B01F 13/00 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
13Other mixers; Mixing plant, including combinations of dissimilar mixers
CPC
B01F 13/0059
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
13Other mixers; Mixing plant, including combinations of ; mixers, e.g. of; dissimilar mixers
0059Micromixers
B01F 13/0093
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
13Other mixers; Mixing plant, including combinations of ; mixers, e.g. of; dissimilar mixers
0059Micromixers
0074using mixing means not otherwise provided for
0093the mixing being achieved by diffusion between layers
B01F 5/0641
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
5Flow mixers
06Mixers in which the components are pressed together through slits, orifices, or screens; ; Static mixers; Mixers of the fractal type
0602Static mixers, i.e. mixers in which the mixing is effected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
0609Mixing tubes, e.g. the material being submitted to a substantially radial movement or to a movement partially in reverse direction
064with means for dividing a flow of material into separate subflows and for repositioning and recombining these subflows; Cross-mixing, e.g. conducting the outer layer of the material nearer to the axis of the tube or vice versa
0641the subflows consisting of at least two flat layers which are recombined, e.g. using means having restriction or expansion zones
B01F 5/0644
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
5Flow mixers
06Mixers in which the components are pressed together through slits, orifices, or screens; ; Static mixers; Mixers of the fractal type
0602Static mixers, i.e. mixers in which the mixing is effected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
0609Mixing tubes, e.g. the material being submitted to a substantially radial movement or to a movement partially in reverse direction
064with means for dividing a flow of material into separate subflows and for repositioning and recombining these subflows; Cross-mixing, e.g. conducting the outer layer of the material nearer to the axis of the tube or vice versa
0644using elements provided with a plurality of channels or using a plurality of tubes which can either be placed between common spaces or collectors
Applicants
  • THE REGENTS OF THE UNIVERSITY OF MICHIGAN [US]/[US] (AllExceptUS)
  • MEINERS, Jens-Christian [DE]/[US] (UsOnly)
  • CHEN, Hao [AR]/[US] (UsOnly)
Inventors
  • MEINERS, Jens-Christian
  • CHEN, Hao
Agents
  • SYROWIK, David, R.
Priority Data
60/532,15723.12.2003US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHOD FOR MIXING FLUID STREAMS, MICROFLUIDIC MIXER AND MICROFLUIDIC CHIP UTILIZING SAME
(FR) PROCEDE POUR MELANGER DES COURANTS DE FLUIDES, MELANGEUR MICROFLUIDIQUE ET PUCE MICROFLUIDIQUE UTILISANT CE PROCEDE
Abstract
(EN)
A method for mixing fluid streams, microfluidic mixer and microfluidic chip utilizing same utilize a topological mixing scheme that exploits the laminarity of the flow to repeatedly fold the flow and exponentially increase the concentration gradients to obtain fast and efficient mixing by diffusion (Figure 1a). It is based on helical flow channels with opposite chiralities that split rotate and recombine the fluid stream in a topology reminiscent of a series of MÖBIUS bands. This geometry is realized in a simple six-stage, two-layer elastomer structure with a footprint of 400 µm x 300 µm per stage that mixes two solutions efficiently at Reynolds numbers between 0.1 and 2. This represents more than an order of magnitude reduction in the size of microfluid mixers that can be manufactured in standard multilayer soft lithography techniques.
(FR)
Un procédé pour mélanger des courants de fluides, un mélangeur microfluidique et une puce microfluidique les utilisant se fondent sur un schéma de mélangeage topologique qui met à profit la laminarité du flux pour dévier plusieurs fois le flux et augmenter de façon exponentielle les gradients de concentration afin de réaliser par diffusion un mélangeage rapide et efficace. On utilise des canaux de flux hélicoïdaux avec des chiralités opposées qui séparent, mettent en rotation et recombinent le courant fluidique selon une topologie qui rappelle une série de bandes de Moebius. Cette géométrie est réalisée dans une structure élastomère à six étages et deux niveaux avec une surface de 400 µm x 300 µm par étage, qui permet de mélanger efficacement les deux solutions avec des nombres de Reynolds entre 0,1 et 2. Cela représente plus qu'un ordre de magnitude en termes de réduction de la taille par rapport aux mélangeurs microfluidiques fabriqués selon des techniques standard de lithographie multicouche souple.
Also published as
US2007177458
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