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1. WO2005063289 - CD40 ANTIBODY FORMULATION AND METHODS

Publication Number WO/2005/063289
Publication Date 14.07.2005
International Application No. PCT/IB2004/004103
International Filing Date 09.12.2004
Chapter 2 Demand Filed 17.12.2004
IPC
A61K 39/395 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
CPC
A61K 2039/545
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
545characterised by the dose, timing or administration schedule
A61K 39/3955
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies
39533against materials from animals
3955against proteinaceous materials, e.g. enzymes, hormones, lymphokines
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 35/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
02specific for leukemia
A61P 37/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
A61P 37/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
04Immunostimulants
Applicants
  • PFIZER PRODUCTS INC. [US]/[US] (AllExceptUS)
  • BEDIAN, Vahe [US]/[US] (UsOnly)
  • CUSMANO, John, Daniel [US]/[US] (UsOnly)
  • GLADUE, Ronald, Paul [US]/[US] (UsOnly)
Inventors
  • BEDIAN, Vahe
  • CUSMANO, John, Daniel
  • GLADUE, Ronald, Paul
Agents
  • FULLER, Grover, F., Jr.
Priority Data
60/531,63922.12.2003US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CD40 ANTIBODY FORMULATION AND METHODS
(FR) FORMULATION D'ANTICORPS CD40 ET MÉTHODES
Abstract
(EN)
The present invention provides a method of treating tumor in a patient comprising administering to said patient a CD40 agonist antibody according to an intermittent dosing schedule. The present invention also provides a method of treating tumor in a patient comprising administering a combination of a CD40 agonist antibody and a DNA replication inhibitor. Also provided is a formulation for use in the treatment.
(FR)
Selon cette méthode de traitement de tumeurs chez un patient, on administre au patient un anticorps agoniste de CD40 selon un plan d'administration intermittente. L'invention concerne également une méthode de traitement de tumeurs chez un patient qui comprend l'administration d'une combinaison d'un anticorps agoniste de CD40 et d'un inhibiteur de la réplication de l'ADN, ainsi qu'une formulation utilisée dans le traitement.
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