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1. (WO2005063286) ANTIBODIES FOR ONCOGENIC STRAINS OF HPV AND METHODS OF THEIR USE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/063286    International Application No.:    PCT/US2004/043356
Publication Date: 14.07.2005 International Filing Date: 23.12.2004
IPC:
A61K 39/12 (2006.01)
Applicants: ARBOR VITA CORPORATION [US/US]; 772 Lucerne Drive, Sunnyvale, CA 94085 (US) (For All Designated States Except US).
LU, Peter, S. [US/US]; (US) (For US Only).
GARMAN, Jonathan, David [US/US]; (US) (For US Only).
BELMARES, Michael, P. [US/US]; (US) (For US Only).
SOMOZA DIAZ-SARMIENTO, Chamorro [ES/US]; (US) (For US Only).
SCHWEIZER, Johannes [DE/US]; (US) (For US Only)
Inventors: LU, Peter, S.; (US).
GARMAN, Jonathan, David; (US).
BELMARES, Michael, P.; (US).
SOMOZA DIAZ-SARMIENTO, Chamorro; (US).
SCHWEIZER, Johannes; (US)
Agent: KEDDIE, James, S.; Bozicevic, Field & Francis LLP, 1900 University Avenue, Suite 200, East Palo Alto, CA 94303 (US)
Priority Data:
60/532,373 23.12.2003 US
Title (EN) ANTIBODIES FOR ONCOGENIC STRAINS OF HPV AND METHODS OF THEIR USE
(FR) ANTICORPS POUR DES SOUCHES ONCOGENES DU HPV ET LEURS METHODES D'UTILISATION
Abstract: front page image
(EN)The subject invention provides antibodies, including polyclonal and monoclonal antibodies, that bind to E6 proteins from at least three oncogenic strains of HPV. In general, the antibodies bind to amino acids motifs that are conserved between the E6 proteins of different HPV strains, particularly HPV strains 16 and 18. The subject antibodies may be used to detect HPV E6 protein in a sample, and, accordingly, the antibodies find use in a variety of diagnostic applications, including methods of diagnosing cancer. Kits for performing the subject methods and containing the subject antibodies are also provided.
(FR)La présente invention concerne des anticorps, y compris des anticorps polyclonaux et monoclonaux, qui se fixent aux protéines E6 d'au moins trois souches oncogènes du HPV. Globalement, les anticorps se fixent à des motifs d'acides aminés qui sont conservés entre les protéines E6 de différentes souches du HPV et plus particulièrement des souches 16 et 18 du HPV. Ces anticorps peuvent être utilisés pour détecter la protéines E6 du HPV dans un échantillon. Par conséquent, ces anticorps peuvent être utilisés pour des applications diagnostiques, y compris dans des méthodes de diagnostic du cancer. L'invention concerne également des trousses destinées à la mise en oeuvre de ces méthodes, contenant lesdits anticorps.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)