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1. (WO2005063170) METHODS OF IDENTIFYING IMMUNOREGULATORY AGENTS, IMMUNOREGULATORY AGENTS, AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/063170    International Application No.:    PCT/JP2004/019846
Publication Date: 14.07.2005 International Filing Date: 28.12.2004
IPC:
G01N 33/50 (2006.01), G01N 33/68 (2006.01), G01N 33/94 (2006.01)
Applicants: TOUDAI TLO, LTD. [JP/JP]; 3-1, Hongou 7-chome, Bunkyo-ku, Tokyo, 1130033 (JP) (For All Designated States Except US).
MORIMOTO, Chikao [JP/JP]; (JP) (For US Only).
OHNUMA, Kei [JP/JP]; (JP) (For US Only)
Inventors: MORIMOTO, Chikao; (JP).
OHNUMA, Kei; (JP)
Agent: SHIMIZU, Hatsushi; Kantetsu Tsukuba Bldg. 6F, 1-1-1, Oroshi-machi, Tsuchiura-shi, Ibaraki, 3000847 (JP)
Priority Data:
60/532,723 29.12.2003 US
Title (EN) METHODS OF IDENTIFYING IMMUNOREGULATORY AGENTS, IMMUNOREGULATORY AGENTS, AND USES THEREOF
(FR) METHODES D'IDENTIFICATION D'AGENTS IMMUNOREGULATEURS, AGENTS IMMUNOREGULATEURS, ET UTILISATIONS ASSOCIEES
Abstract: front page image
(EN)The present invention provides methods of identifying a substance that down-regulates or up-regulates an immune response and kits used for the identification methods. A method of this invention comprises detecting a substance that inhibits or enhances the interaction between CD26 and caveolin-1. Another method comprises detecting a substance that inhibits or enhances the interaction between caveolin-1 and Tollip. Still another method comprises detecting a substance that inhibits or enhances the interaction among caveolin-1, Tollip, and IRAK-1. The present invention also relates to immunoregulatory agents comprising a substance that down-regulates an immune response, such as siRNA against caveolin-1 or Tollip. The invention further provides immunoregulatory agents comprising a substance that up-regulates an immune response. These agents are useful for treating inflammatory diseases, autoimmune diseases, or other immune-mediated disorders.
(FR)L'invention concerne des méthodes d'identification d'une substance qui régule à la hausse ou à la baisse une réaction immunitaire et des kits utilisés dans ces méthodes d'identification. Une méthode de l'invention consiste à détecter une substance qui inhibe ou qui accroît l'interaction entre CD26 et cavéoline-1. Une autre méthode consiste à détecter une substance qui inhibe ou qui accroît l'interaction entre cavéoline-1 et Tollip. Une autre méthode consiste à détecter une substance qui inhibe ou qui accroît l'interaction entre cavéoline-1, Tollip, et IRAK-1. L'invention concerne également des agents immunorégulateurs comprenant une substance qui régule à la baisse une réaction immunitaire, de type petit ARN interférent contre cavéoline-1 ou Tollip. L'invention concerne en outre des agents immunorégulateurs comprenant une substance qui régule à la hausse une réaction immunitaire. Ces agents servent à traiter des maladies inflammatoires, des maladies auto-immunes, ou d'autres troubles à médiation immunitaire.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)