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Machine translation
1. (WO2005063009) A PROCEDURE FOR SCREENING OF NEUROACTIVE SUBSTANCE AND THE ASSOCIATED NEURAL PLASTICITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/063009    International Application No.:    PCT/IN2003/000402
Publication Date: 14.07.2005 International Filing Date: 29.12.2003
Chapter 2 Demand Filed:    28.07.2005    
IPC:
A01K 67/033 (2006.01), A61K 49/00 (2006.01), G01N 33/50 (2006.01)
Applicants: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH [IN/IN]; Rafi Marg, 110 001 New Delhi (IN) (For All Designated States Except US).
SHARMA, Abhay [IN/IN]; (IN) (For US Only)
Inventors: SHARMA, Abhay; (IN)
Agent: GABRIEL, Devadoss, Calab; K & S PARTNERS, 84-C, C-6 Lane, Off Central Avenue, Sainik Farms, 110 062 New Delhi (IN)
Priority Data:
Title (EN) A PROCEDURE FOR SCREENING OF NEUROACTIVE SUBSTANCE AND THE ASSOCIATED NEURAL PLASTICITY
(FR) PROCEDE PERMETTANT DE CRIBLER UNE SUBSTANCE NEURO-ACTIVE ET LA PLASTICITE NEURONALE ASSOCIEE
Abstract: front page image
(EN)The invention relates to a procedure for screening of neuroactive substance and the associated neural plasticity by treating the fruitfly Drosophila melanogaster adult males with fly medium containing either of the neuroactive compounds strychnine, pentylenetetrazol, pilocarpine hydrochloride, tetraethylammonium chloride, lithium carbonate and ethosuximide, subjecting flies to negative geotaxis and horizontal locomotor assays, observing the height climbed and distance walked by and the climbing speed of the flies wherein an altered height climbed by flies under drug treatment and a long-lasting alteration in climbing speed of flies after drug withdrawal is most characteristic of the neuractive compounds.
(FR)Cette invention concerne un procédé permettant de cribler une substance neuro-active et la plasticité neuronale associée par traitement des mâles adultes de l'espèce Drosophila melanogaster au moyen d'un milieu de culture de mouches contenant l'un des composés actifs suivants : la strychnine, le pentylènetetrazol, le chlorhydrate de pilocarpine, le chlorure de tétraéthylammonium, le carbonate de lithium et l'éthosuximide ; à soumettre les mouches à une géotaxie négative et à des tests locomoteurs horizontaux ; à observer la hauteur de la montée et la distance parcourue ainsi que la vitesse de montée des mouches, une hauteur de montée modifiée après prise de médicaments et une altération de longue durée de la vitesse de montée des mouches après élimination des médicaments étant caractéristiques des composés neuro-actifs.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)