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1. (WO2005062882) RIFAMYCIN ANALOGS AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/062882    International Application No.:    PCT/US2004/043093
Publication Date: 14.07.2005 International Filing Date: 21.12.2004
IPC:
C07D 498/14 (2006.01), C07D 491/14 (2006.01), A61K 31/542 (2006.01), A61K 31/5383 (2006.01), A61K 31/498 (2006.01), A61P 31/04 (2006.01), A61P 31/10 (2006.01)
Applicants: ACTIVBIOTICS, INC [US/US]; 128 Spring Street, Lexington, MA 02421 (US) (For All Designated States Except US).
VAN DUZER, John, H. [US/US]; (US) (For US Only).
MICHAELIS, Arthur, F. [US/US]; (US) (For US Only).
GEISS, William, B. [US/US]; (US) (For US Only).
STAFFORD, Douglas, G. [US/US]; (US) (For US Only).
RAKER, Joseph [US/US]; (US) (For US Only).
YU, Xiang, Y. [US/US]; (US) (For US Only).
SIEDLECKI, James, M. [US/US]; (US) (For US Only).
YANG, Yingfei [CN/US]; (US) (For US Only)
Inventors: VAN DUZER, John, H.; (US).
MICHAELIS, Arthur, F.; (US).
GEISS, William, B.; (US).
STAFFORD, Douglas, G.; (US).
RAKER, Joseph; (US).
YU, Xiang, Y.; (US).
SIEDLECKI, James, M.; (US).
YANG, Yingfei; (US)
Agent: ELBING, Karen, L.; Clark & Elbing LLP, 101 Federal Street, Boston, MA 02110 (US)
Priority Data:
60/532,237 23.12.2003 US
Title (EN) RIFAMYCIN ANALOGS AND USES THEREOF
(FR) ANALOGUES DE RIFAMYCINE ET LEURS UTILISATIONS
Abstract: front page image
(EN)The present invention features rifamycin analogs that can be used as therapeutics for treating or preventing a variety of microbial infections. In one form, the analogs are acetylated at the 25-position, as is rifamycin. In another form, the analogs are deacetylated at the 25-position. In yet other forms, benzoxazinorifamycin, benzthiazinorifamycin, and benzdiazinorifamycin analogs are derivatized at various positions of the benzene ring, including 3’-hydroxy analogs, 4’-and/or 6’ halo and/or alkoxy analogs, and various 5’ substituents that incorporate a cyclic amine moiety.
(FR)L'invention concerne des analogues de rifamycine que l'on peut utiliser comme agents thérapeutiques dans le traitement ou la prévention de diverses infections microbiennes. Dans une forme, les analogues sont acétylés en position 25, comme la rifamycine. Dans une autre forme, ils sont déacétylés en position 25. Dans d'autres formes encore, des analogues de benzoxazinorifamycine, benzthiazinorifamycine et benzdiazinorifamycine sont dérivés à des positions diverses du cycle benzénique, notamment des analogues 3'-hydroxy, 4'- et/ou 6' halo et/ou alcoxy, et divers 5' substituants comprenant un fragment amine cyclique.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)