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Pub. No.:    WO/2005/061547    International Application No.:    PCT/EP2004/014643
Publication Date: 07.07.2005 International Filing Date: 22.12.2004
C07K 16/28 (2006.01), C07K 16/30 (2006.01), C07K 16/46 (2006.01)
Applicants: MICROMET AG [DE/DE]; Staffelseestrasse 2, 81477 München (DE) (For All Designated States Except US).
KUFER, Peter [DE/DE]; (DE) (For US Only).
BERRY, Meera [IN/DE]; (DE) (For US Only).
BAEUERLE, Patrick [DE/DE]; (DE) (For US Only).
ITIN, Christian [CH/DE]; (DE) (For US Only)
Inventors: KUFER, Peter; (DE).
BERRY, Meera; (DE).
BAEUERLE, Patrick; (DE).
ITIN, Christian; (DE)
Agent: DEHMEL, Albrecht; Dehmel & Bettenhausen, Herzogspitalstr. 11, 80331 München (DE)
Priority Data:
10/743,697 22.12.2003 US
Abstract: front page image
(EN)A bispecific antibody comprising two antibody variable domains on a single polypeptide chain, wherein a first portion of the bispecific antibody is capable of recruiting the activity of a human immune effector cell by specifically binding to an effector antigen on the human immune effector cell, said first portion consisting of one antibody variable domain, and a second portion of the bispecific antibody specifically binds to a target antigen other than the effector antigen, said target antigen on a target cell other than said human immune effector cell, and said second portion comprising one antibody variable domain.
(FR)L'invention concerne un anticorps bispécifique comprenant deux domaines variables d'anticorps sur une seule chaîne polypeptidique. Une première partie de l'anticorps bispécifique est capable de recruter l'activité d'une cellule effectrice immunitaire humaine par fixation spécifique sur un antigène effecteur sur la cellule effectrice immunitaire humaine, la première partie comportant un domaine variable d'anticorps. Une seconde partie de l'anticorps bispécifique se fixe de manière spécifique à un antigène cible autre que l'antigène effecteur, ledit antigène cible sur une cellule cible autre que ladite cellule effectrice immunitaire humaine, et ladite seconde partie comprenant un domaine variable d'anticorps.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)