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Machine translation
1. (WO2005061498) SUBSTITUTED 1H-PYRROLO[3,2-B, 3,2-C, AND 2,3-C]PYRIDINE-2-CARBOXAMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I EPSILON
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/061498    International Application No.:    PCT/US2004/040080
Publication Date: 07.07.2005 International Filing Date: 01.12.2004
IPC:
A61K 31/437 (2006.01), C07D 471/04 (2006.01)
Applicants: AVENTIS PHARMACEUTICALS INC. [US/US]; 300 Somerset Corporate Boulevard, Bridgewater, New Jersey 08807-2854 (US) (For All Designated States Except US).
METZ, William, A. [US/US]; (US) (For US Only).
HALLEY, Frank [FR/FR]; (FR) (For US Only).
DUTRUC-ROSSET, Gilles [FR/FR]; (FR) (For US Only).
CHOI-SLEDESKI, Yong, Mi [US/US]; (US) (For US Only).
POLI, Gregory, B. [US/US]; (US) (For US Only).
FINK, David, M. [US/US]; (US) (For US Only).
DOERFLINGER, Gilles [FR/FR]; (FR) (For US Only).
HUANG, Bao-Guo [CN/US]; (US) (For US Only).
GELORMINI, Ann, Marie [US/US]; (US) (For US Only).
GAMBOA, Juan, A. [US/US]; (US) (For US Only).
GIOVANNI, Andrew [US/US]; (US) (For US Only).
ROEHR, Joachim, E. [DE/US]; (US) (For US Only).
TSAY, Joseph, T. [US/US]; (US) (For US Only).
CAMACHO, Fernando [US/US]; (US) (For US Only).
HURST, William, J. [US/US]; (US) (For US Only).
HARNISH, Stephen, W. [US/US]; (US) (For US Only).
CHIANG, Yulin [US/US]; (US) (For US Only)
Inventors: METZ, William, A.; (US).
HALLEY, Frank; (FR).
DUTRUC-ROSSET, Gilles; (FR).
CHOI-SLEDESKI, Yong, Mi; (US).
POLI, Gregory, B.; (US).
FINK, David, M.; (US).
DOERFLINGER, Gilles; (FR).
HUANG, Bao-Guo; (US).
GELORMINI, Ann, Marie; (US).
GAMBOA, Juan, A.; (US).
GIOVANNI, Andrew; (US).
ROEHR, Joachim, E.; (US).
TSAY, Joseph, T.; (US).
CAMACHO, Fernando; (US).
HURST, William, J.; (US).
HARNISH, Stephen, W.; (US).
CHIANG, Yulin; (US)
Agent: MARTIN, Lawrence, L.; Aventis Pharmaceuticals Inc., Route 202-206 P.O. Box 6800, Bridgewater, NJ 08807-0800 (US)
Priority Data:
60/528,764 11.12.2003 US
Title (EN) SUBSTITUTED 1H-PYRROLO[3,2-B, 3,2-C, AND 2,3-C]PYRIDINE-2-CARBOXAMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I EPSILON
(FR) CARBOXAMIDES 1H-PYRROLO[3,2-B, 3,2-C, ET 2,3-C]PYRIDINE-2- SUBSTITUES ET LEURS ANALOGUES UTILISES EN TANT QU'INHIBITEURS DE LA CASEINE KINASE I$G(E)
Abstract: front page image
(EN)The present invention discloses and claims substituted 1H-pyrrolo[3,2-b]pyridine-2-carboxamides, 1H-pyrrolo[3,2-c]pyridine-2-carboxamides and 1H-pyrrolo[2,3-c]pyridine-2-carboxamides (compounds of formula (I)) as inhibitors of human casein kinase I Epsilon, and methods of using said compounds of formula (I) for treating central nervous system diseases and disorders including mood disorders and sleep disorders. Pharmaceutical compositions comprising compounds of formula (I) and methods for the preparation of compounds of formula (I) are also disclosed and claimed.
(FR)La présente invention concerne des carboxamides 1H-pyrrolo[3,2-b]pyridine-2- substitués, des carboxamides 1H-pyrrolo[3,2-c]pyridine-2- et des carboxamides 1H-pyrrolo[2,3-c]pyridine-2- (des composés de formule (I)) utilisés en tant qu'inhibiteurs de la caséine kinase I$g(e) humaine, ainsi que des méthodes d'utilisation desdits composés de formule (I) dans le traitement de maladies et de troubles du système nerveux central, y compris, des troubles de l'humeur et du sommeil. Cette invention a aussi pour objet des compositions pharmaceutiques renfermant des composés de formule (I) et leurs méthodes de préparation.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)