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1. (WO2005061492) NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND DRUGS COMPRISING THE SAME AS THE ACTIVE INGREDIENT
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/061492    International Application No.:    PCT/JP2004/019660
Publication Date: 07.07.2005 International Filing Date: 21.12.2004
IPC:
A61K 31/427 (2006.01), A61P 9/00 (2006.01), A61P 27/02 (2006.01), A61P 27/04 (2006.01), A61P 27/06 (2006.01), A61P 27/10 (2006.01), A61P 27/12 (2006.01), A61P 43/00 (2006.01), C07D 417/12 (2006.01)
Applicants: ONO PHARMACEUTICAL CO., LTD. [JP/JP]; 1-5, Doshomachi 2-chome Chuo-ku, Osaka-shi Osaka 541-8526 (JP) (For All Designated States Except US).
YAMANE, Shinsaku [JP/JP]; (JP) (For US Only).
NARITA, Masami [JP/JP]; (JP) (For US Only).
TANI, Kousuke [JP/JP]; (JP) (For US Only).
KOBAYASHI, Kaoru [JP/JP]; (JP) (For US Only)
Inventors: YAMANE, Shinsaku; (JP).
NARITA, Masami; (JP).
TANI, Kousuke; (JP).
KOBAYASHI, Kaoru; (JP)
Agent: OHIE, Kunihisa; Ohie Patent Office Selva-Ningyocho 6F 14-6, Nihonbashi-Ningyocho 2-chome Chuo-ku, Tokyo 103-0013 (JP)
Priority Data:
2003-425400 22.12.2003 JP
Title (EN) NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND DRUGS COMPRISING THE SAME AS THE ACTIVE INGREDIENT
(FR) COMPOSES HETEROCYCLIQUES AZOTES ET MEDICAMENTS DONT ILS SONT LE PRINCIPE ACTIF
(JA) 含窒素複素環化合物およびそれらを有効成分とする薬剤
Abstract: front page image
(EN)Compounds represented by the following general formula (I): (I) wherein each symbol is as defined in the description; salts thereof, solvates thereof, prodrugs thereof or cyclodextrin clathrates thereof. Because of having a potent agonism to EP2 and a potent effect of lowering ocular tension while little irritating the eye, these compounds are useful in treating eye diseases such as glaucoma, ocular hypertension, macular edema, macular degeneration, blood flow loss in retinal and optic nerve papillae, retinal and optic nerve hypertension, myopia, hyperopia, astigma, dry eye, retinal detachment, cataract and so on.
(FR)L'invention porte sur des composés de formule générale (I) dans laquelle: chaque symbole est tel que défini dans la description, et sur ses sels, solvates, prodrogues, ou clathrates de cyclodextrine. En raison de leur agonisme puissant de l'EP2, de leur puissant effet sur l'abaissement de la tension oculaire, et de leur absence de pouvoir irritant, ces composés s'avèrent utiles pour traiter le glaucome, l'hypertension oculaire, l'oedème maculaire, la dégénérescence maculaire, les hémorragies rétiniennes et des papilles du nerf optique, l'hypertension du nerf optique, la myopie, l'hypermétropie, l'astigmatisme, la sécheresse de l'oeil, le décollement de la rétine, la cataracte, etc.
(JA)not available
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)