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1. (WO2005061459) BIARYL SULFONAMIDES AND METHODS FOR USING SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/061459    International Application No.:    PCT/US2003/041173
Publication Date: 07.07.2005 International Filing Date: 22.12.2003
IPC:
C07C 311/29 (2006.01), C07C 311/46 (2006.01), C07D 213/30 (2006.01), C07D 213/64 (2006.01), C07D 213/643 (2006.01), C07D 215/14 (2006.01), C07D 215/227 (2006.01), C07D 215/233 (2006.01), C07D 217/18 (2006.01), C07D 235/12 (2006.01), C07D 239/34 (2006.01), C07D 239/60 (2006.01), C07D 261/14 (2006.01), C07D 263/22 (2006.01), C07D 263/58 (2006.01), C07D 277/64 (2006.01), C07D 277/68 (2006.01), C07D 295/096 (2006.01), C07D 295/192 (2006.01), C07D 307/79 (2006.01), C07D 307/80 (2006.01), C07D 307/82 (2006.01), C07D 307/84 (2006.01), C07D 319/18 (2006.01), C07D 321/10 (2006.01), C07D 333/20 (2006.01), C07D 333/36 (2006.01), C07D 333/66 (2006.01)
Applicants: WYETH [US/US]; Five Giralda Farms, Madison, NJ 07940-0874 (US) (For All Designated States Except US).
XIANG, Jason, Shaoyun [US/US]; (US) (For US Only).
TAM, Steve, Yik-Kai [US/US]; (US) (For US Only).
HU, Yonghan [CN/US]; (US) (For US Only).
SUM, Phaik-Eng [CA/US]; (US) (For US Only).
HOW, David, Brian [CA/US]; (US) (For US Only).
HOPPER, Darrin, William [US/US]; (US) (For US Only).
VERA, Matthew, Douglas [US/US]; (US) (For US Only).
SABATINI, Joshua, James [US/US]; (US) (For US Only).
RUSH, Thomas, Saltmarsh, III [US/US]; (US) (For US Only).
MORRIS, Elisabeth, Ann [US/US]; (US) (For US Only).
GEORGIADIS, Katy, Evangelia [US/US]; (US) (For US Only)
Inventors: XIANG, Jason, Shaoyun; (US).
TAM, Steve, Yik-Kai; (US).
HU, Yonghan; (US).
SUM, Phaik-Eng; (US).
HOW, David, Brian; (US).
HOPPER, Darrin, William; (US).
VERA, Matthew, Douglas; (US).
SABATINI, Joshua, James; (US).
RUSH, Thomas, Saltmarsh, III; (US).
MORRIS, Elisabeth, Ann; (US).
GEORGIADIS, Katy, Evangelia; (US)
Agent: LUCCI, Joseph; Woodcock Washburn LLP, 46th Floor, One Liberty Place, Philadelphia, PA 19103 (US)
Priority Data:
60/526,883 04.12.2003 US
Title (EN) BIARYL SULFONAMIDES AND METHODS FOR USING SAME
(FR) SULFONAMIDES DE BIARYLE ET PROCEDES D'UTILISATION
Abstract: front page image
(EN)The present invention relates to biaryl sulfonamides of the formula 1: wherein: R1 is H or Cl-.C6 a]kyl; R2 is H, C I -C6 alkyl, (CH2)nR2' , phenyl, or benzyl; n is 0-6; R2'is aryl, heteroaryl, cycloalkyl, or heterocycloalkyl; R 3 is, independently with respect to each occurrence, H, halogen, OC(halogen)3,C(halogen)3, alkoxy, or C I -C 6 alkyl; X is selected from CH20, OCH2, C (R3)=(R3)2-C(R3)2, CH2NHC(=O), O(C=O)NH, O, C(=O)CH2, SO2CH2C(=O)NH, SO2NH, OC(=O), CH2S(O), and CH2S(O)2; and Z is at least one aryl or heteroaryl moiety, and their use as for example metalloproteinase inhibitors.
(FR)L'invention concerne des sulfonamides de biaryle de formule 1. R1 est H ou alkyle Cl-.C6; R2 est H, alkyle CI -C6, (CH2)nR2', phényle, ou benzyle; n vaut de 0 à 6; R2'est aryle, hétéroaryle, cycloalkyle, ou hétérocycloalkyle; R 3 est, indépendamment de chaque occurrence, H, halogène, OC(halogène)3,C(halogène)3, alcoxy, ou alkyle CI -C6; X peut être CH20, OCH2, C (R3)=(R3)2-C(R3)2, CH2NHC(=O), O(C=O)NH, O, C(=O)CH2, SO2CH2C(=O)NH, SO2NH, OC(=O), CH2S(O), et CH2S(O)2; et Z est au moins une fraction aryle ou hétéroaryle. L'invention concerne également l'utilisation des ces produits comme inhibiteurs de métalloprotéinase, par exemple.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)