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1. WO2005061075 - MAGNETIC SEPARATION APPARATUS AND METHODS

Publication Number WO/2005/061075
Publication Date 07.07.2005
International Application No. PCT/US2004/031132
International Filing Date 22.09.2004
Chapter 2 Demand Filed 09.07.2005
IPC
B03C 1/00 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
1Magnetic separation
CPC
B03C 1/002
BPERFORMING OPERATIONS; TRANSPORTING
03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
1Magnetic separation
002High gradient magnetic separation
B03C 2201/18
BPERFORMING OPERATIONS; TRANSPORTING
03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
2201Details of magnetic or electrostatic separation
18Magnetic separation whereby the particles are suspended in a liquid
B03C 2201/26
BPERFORMING OPERATIONS; TRANSPORTING
03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
2201Details of magnetic or electrostatic separation
26for use in medical applications
Y10T 436/25375
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
10TECHNICAL SUBJECTS COVERED BY FORMER USPC
TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
436Chemistry: analytical and immunological testing
25including sample preparation
25375Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
Applicants
  • IMMUNIVEST CORPORATION [US]/[US] (AllExceptUS)
  • TYCHO, Scholtens [NL]/[NL] (UsOnly)
  • LEON, W,. M,. M., Terstappen [NL]/[US] (UsOnly)
  • ARJAN, Tibbe [NL]/[NL] (UsOnly)
Inventors
  • TYCHO, Scholtens
  • LEON, W,. M,. M., Terstappen
  • ARJAN, Tibbe
Agents
  • ACETO, Joseph
Priority Data
10/733,82910.12.2003US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MAGNETIC SEPARATION APPARATUS AND METHODS
(FR) METHODES ET APPAREIL DE SEPARATION MAGNETIQUE
Abstract
(EN)
Apparatuses and methods for separating, immobilizing, and quantifying biological substances from within a fluid medium. Biological substances are observed by employing a vessel (6) having a chamber therein, the vessel comprising a transparent collection wall (5). A high internal gradient magnetic capture structure may be on the transparent collection wall (5), magnets (3) create an extemally-applied force for transporting magnetically responsive material toward the transparent collection wall (5). V-shaped grooves on the inner surface of the viewing face of the chamber provide uniform . The invention is also useful in conducting quantitative analysis and sample preparation in conjunction with automated cell enumeration techniques.
(FR)
L'invention concerne des appareils et des méthodes pour séparer, pour immobiliser et pour quantifier des substances biologiques à partir d'un milieu fluide. Les substances biologiques sont observées au moyen d'un contenant (6) présentant un compartiment. Le contenant comprend une paroi transparente de recueillement (5). Une structure de capture magnétique à gradient intérieur élevé peut se trouver sur la paroi transparente de recueillement (5). Des aimants (3) créent une force appliquée de manière extérieure pour transporter magnétiquement un matériau réagissant par rapport à la paroi transparente de recueillement (5). Des rainures en forme de V sont situées sur la surface intérieure de la face de visualisation du compartiment. L'invention est également utile pour effectuer une analyse quantitative et une préparation d'échantillon, conjointement à des techniques d'énumération cellulaire automatique.
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