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1. (WO2005060739) TRANSGENIC NON-HUMAN MAMMAL COMPRISING A POLYNUCLEOTIDE ENCODING HUMAN OR HUMANIZED C5AR
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2005/060739 International Application No.: PCT/AU2004/001844
Publication Date: 07.07.2005 International Filing Date: 24.12.2004
IPC:
A01K 67/027 (2006.01) ,C12N 15/00 (2006.01)
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
K
ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67
Rearing or breeding animals, not otherwise provided for; New breeds of animals
027
New breeds of vertebrates
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
Applicants: MACKAY, Charles, Reay[AU/AU]; AU (UsOnly)
G2 INFLAMMATION PTY LTD[AU/AU]; Level 10, 384 Victoria Street Darlinghurst, New South Wales 2010, AU (AllExceptUS)
Inventors: MACKAY, Charles, Reay; AU
Agent: FB RICE & CO; 139 Rathdowne Street Carlton, Victoria 3053, AU
Priority Data:
200390715024.12.2003AU
Title (EN) TRANSGENIC NON-HUMAN MAMMAL COMPRISING A POLYNUCLEOTIDE ENCODING HUMAN OR HUMANIZED C5AR
(FR) MAMMIFERE TRANSGENIQUE NON HUMAIN COMPRENANT UN POLYNUCLEOTIDE CODANT POUR UN RECEPTEUR C5AR HUMAIN OU HUMANISE
Abstract:
(EN) The present invention relates to transgenic non-human mammals comprising a polynucleotide encoding a human or humanized C5aR. The invention also relates to use of the transgenic non-human mammals in methods of screening for agonists, inverse agonists and antagonists of human C5aR and for testing efficacy of C5aR agonists, inverse agonists and antagonists in various animal models of disease.
(FR) L'invention concerne des mammifères transgéniques non humains comprenant un polynucléotide codant pour un récepteur C5aR humain ou humanisé. L'invention concerne également l'utilisation de mammifères transgéniques non humains dans des procédés de criblage destinés à identifier des agonistes, des agonistes inverses et des antagonistes du récepteur C5aR humain, et à mesurer l'efficacité des agonistes, des agonistes inverses et des antagonistes de C5aR dans divers modèles animaux de pathologies.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)