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Machine translation
1. (WO2005060627) METHODS OF ASSESSING THE RISK OF NON-TRAUMATIC BONE FRACTURE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/060627    International Application No.:    PCT/US2004/041489
Publication Date: 07.07.2005 International Filing Date: 10.12.2004
IPC:
G01N 33/53 (2006.01), G01N 33/566 (2006.01)
Applicants: AUXERIS THERAPEUTICS, INC. [US/US]; 4041 Forest Park Boulevard, St. Louis, MO 63108 (US) (For All Designated States Except US).
SCHETT, Georg [AT/AT]; (AT) (For US Only).
KIECHL, Stefan [AT/AT]; (AT) (For US Only).
WILLEIT, Johann [AT/AT]; (AT) (For US Only)
Inventors: SCHETT, Georg; (AT).
KIECHL, Stefan; (AT).
WILLEIT, Johann; (AT)
Agent: JACKSON, David, A.; Klauber & Jackson, 411 Hackensack Avenue, Hackensack, NJ 07601 (US)
Priority Data:
60/528,377 10.12.2003 US
Title (EN) METHODS OF ASSESSING THE RISK OF NON-TRAUMATIC BONE FRACTURE
(FR) METHODES PERMETTANT D'EVALUER UN RISQUE DE FRACTURE OSSEUSE NON TRAUMATIQUE
Abstract: front page image
(EN)The present invention relates to the identification of RANK ligand (RANKL) as associated with and useful as a marker of bone metabolism conditions and particularly of predicting risk of non-­traumatic bone fractures. The invention also relates to assays, methods and kits comprising RANKL and/or antibodies thereto for screening, diagnosis, prediction and monitoring. This invention provides methods for determining a subject's risk of non-traumatic bone fracture, comprising determining the subject's level of RANKL, particularly of soluble uncomplexed RANKL.
(FR)L'invention concerne l'identification d'un ligand RANK (RANKL) associé à un marqueur et utilisé comme marqueur de conditions métaboliques osseuses, et plus particulièrement la prédiction d'un risque de fractures osseuses non traumatiques. L'invention concerne également des dosages, des méthodes et des kits comprenant RANKL et/ou des anticorps contre celui-ci à des fins de criblage, de diagnostic, de prédiction et de surveillance. L'invention concerne enfin des méthodes permettant de déterminer un risque de fracture osseuse non traumatique chez un sujet, qui consistent à déterminer le niveau de RANKL chez ce sujet, en particulier, le niveau d'un RANKL soluble non complexé.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)