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1. (WO2005060375) METHODS OF THERAPY AND DIAGNOSIS USING TARGETING OF CELLS THAT EXPRESS KILLER CELL IMMUNOGLOBULIN-LIKE RECEPTOR-LIKE PROTEIN
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/060375    International Application No.:    PCT/US2004/011171
Publication Date: 07.07.2005 International Filing Date: 13.04.2004
Chapter 2 Demand Filed:    18.10.2004    
IPC:
C07H 21/02 (2006.01)
Applicants: NUVELO, INC. [US/US]; 675 Almanor Avenue, Sunnyvale, CA 94085 (US) (For All Designated States Except US).
EMTAGE, Peter, C.R. [CA/US]; (US) (For US Only)
Inventors: EMTAGE, Peter, C.R.; (US)
Agent: POLIZOTTO, Renee; NUVELO, Inc., 675 Almanor Avenue, Sunnyvale, CA 94085 (US)
Priority Data:
10/727,012 02.12.2003 US
Title (EN) METHODS OF THERAPY AND DIAGNOSIS USING TARGETING OF CELLS THAT EXPRESS KILLER CELL IMMUNOGLOBULIN-LIKE RECEPTOR-LIKE PROTEIN
(FR) PROCEDES DE THERAPIE ET DE DIAGNOSTIC REPOSANT SUR LE CIBLAGE DE CELLULES QUI EXPRIMENT UNE PROTEINE DU TYPE RECEPTEUR DE TYPE IMMOGLOBULINE DE CELLULE TUEUSE.
Abstract: front page image
(EN)Certain cells, including types of cancer cells such as KIRHy1, are capable of expressing KIRHy1 mRNA. Targeting using KIRHy1 polypeptides, nucleic acids encoding for KIRHy1 polypeptides and anti-KIRHy1 antibodies provides a method of killing or inhibiting that growth of cancer cells that express the KIRHy1 protein. Methods of therapy and diagnosis of disorders associated with KIRHy1 protein-expressing cells, such as acute myelogenous leukemia (AML), are described.
(FR)Sachant que certaines cellules, y compris des types de cellules cancéreuses comme KIRHy1 sont capables d'exprimer de l'ARNm de KIRHy1, le ciblage reposant sur des polypeptides KIRHy1, des acides nucléiques qui codent ces polypeptides et des anticorps anti-KIRHy1 constitue un procédé de destruction ou d'inhibition de la croissance cancéreuse qui exprime la protéine KIRHy1. L'invention concerne également des procédés de thérapie et de diagnostic des troubles associés aux cellules exprimant ladite protéine KIRHy1, comme les cellules de la leucémie myélogène aiguë.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)