WO2005058790 COMPOUNDS HAVING LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISM AND USES THEREOF

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Publication Number WO/2005/058790

Publication Date 30.06.2005

International Application No. PCT/JP2004/019456

International Filing Date 17.12.2004

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Applicants

小野薬品工業株式会社 ONO PHARMACEUTICAL CO., LTD. [JP]/[JP] (AllExceptUS)
田中元之 TANAKA, Motoyuki [JP]/[JP] (UsOnly)
中出眞嗣 NAKADE, Shinji [JP]/[JP] (UsOnly)
高岡義和 TAKAOKA, Yoshikazu [JP]/[JP] (UsOnly)

Inventors

田中元之 TANAKA, Motoyuki
中出眞嗣 NAKADE, Shinji
高岡義和 TAKAOKA, Yoshikazu

Agents

大家邦久 OHIE, Kunihisa

Priority Data

2003-422431		19.12.2003		JP
2004-101378		30.03.2004		JP

Publication Language Japanese (ja)

Filing Language Japanese (JA)

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Title

(EN) COMPOUNDS HAVING LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISM AND USES THEREOF

(FR) COMPOSES ANTAGONISTES DES RECEPTEURS A L'ACIDE LYSOPHOSPHATIDIQUE ET LEURS UTILISATIONS

(JA) リゾホスファチジン酸受容体拮抗作用を有する化合物およびその用途

Abstract

(EN) Compounds represented by the general formula (I), salts of the same, solvates of both, or prodrugs thereof: (I) (wherein each symbol is as defined in the description). Since the compounds of the invention bind to LPA receptors (particularly EDG-2) and thus antagonize them, they are useful in the prevention and/or treatment of urologic diseases (such as symptoms due to prostatic hypertrophy or neurogenic bladder; tumor of spinal cord; intervertebral disk hernia; spinal canal stenosis; symptoms caused by diabetes; obstruction of lower urinary tract; inflammatory diseases of lower urinary tract; and polyuria), cancer-related diseases, proliferative diseases, inflammatory diseases, immunopathies, diseases due to secretion disturbance, brain-related diseases and/or chronic diseases.

(FR) La présente invention se rapporte à des composés représentés par la formule (I), dans laquelle chaque élément est tel que défini dans le descriptif de l'invention, à des sels de ces derniers, et à des solvates ou à des promédicaments desdits composés et sels. Etant donné qu'ils se lient aux récepteurs LPA (en particulier à EDG-2) et constituent donc des antagonistes de ces derniers, les composés selon l'invention sont utiles pour prévenir et/ou traiter des maladies urologiques (telles que les symptômes de l'hypertrophie prostatique ou de la vessie neurogène, les tumeurs de la moelle épinière, les hernies discales, la sténose du canal rachidien, les symptômes du diabète, l'obstruction du tractus urinaire inférieur, les maladies inflammatoires du tractus urinaire inférieur et la polyurie), des maladies associées au cancer, des maladies prolifératives, des maladies inflammatoires, des immunopathies, des maladies dues à des troubles sécrétoires, des maladies cérébrales et/ou des maladies chroniques.

(JA) not available

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
C	ACYCLIC OR CARBOCYCLIC COMPOUNDS
59	Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O-metal, -CHO, keto, ether, groups, groups, or groups
40	Unsaturated compounds
58	containing ether groups, groups, groups, or groups
64	containing six-membered aromatic rings
66	the non-carboxylic part of the ether containing six-membered aromatic rings

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
C	ACYCLIC OR CARBOCYCLIC COMPOUNDS
69	Esters of carboxylic acids; Esters of carbonic or haloformic acids
66	Esters of carboxylic acids having esterified carboxyl groups bound to acyclic carbon atoms and having any of the groups OH, O-metal, -CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
73	of unsaturated acids
734	Ethers

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
C	ACYCLIC OR CARBOCYCLIC COMPOUNDS
69	Esters of carboxylic acids; Esters of carbonic or haloformic acids
76	Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a six-membered aromatic ring
84	of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
92	with etherified hydroxyl groups

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
C	ACYCLIC OR CARBOCYCLIC COMPOUNDS
59	Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O-metal, -CHO, keto, ether, groups, groups, or groups
40	Unsaturated compounds
58	containing ether groups, groups, groups, or groups
64	containing six-membered aromatic rings
66	the non-carboxylic part of the ether containing six-membered aromatic rings

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
C	ACYCLIC OR CARBOCYCLIC COMPOUNDS
69	Esters of carboxylic acids; Esters of carbonic or haloformic acids
66	Esters of carboxylic acids having esterified carboxyl groups bound to acyclic carbon atoms and having any of the groups OH, O-metal, -CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
73	of unsaturated acids
734	Ethers

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1. WO2005058790 - COMPOUNDS HAVING LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISM AND USES THEREOF

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1	Drugs for disorders of the alimentary tract or the digestive system
10	Laxatives

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
207	Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02	with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
30	having two double bonds between ring members or between ring members and non-ring members
32	with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
33	with substituted hydrocarbon radicals, directly attached to ring carbon atoms
337	Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals