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1. (WO2005058790) COMPOUNDS HAVING LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISM AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2005/058790 International Application No.: PCT/JP2004/019456
Publication Date: 30.06.2005 International Filing Date: 17.12.2004
IPC:
C07C 59/66 (2006.01) ,C07C 69/734 (2006.01) ,C07C 69/92 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
59
Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O-metal, -CHO, keto, ether, groups, groups, or groups
40
Unsaturated compounds
58
containing ether groups, groups, groups, or groups
64
containing six-membered aromatic rings
66
the non-carboxylic part of the ether containing six-membered aromatic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
69
Esters of carboxylic acids; Esters of carbonic or haloformic acids
66
Esters of carboxylic acids having esterified carboxyl groups bound to acyclic carbon atoms and having any of the groups OH, O-metal, -CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
73
of unsaturated acids
734
Ethers
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
69
Esters of carboxylic acids; Esters of carbonic or haloformic acids
76
Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a six-membered aromatic ring
84
of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
92
with etherified hydroxyl groups
Applicants:
田中 元之 TANAKA, Motoyuki [JP/JP]; JP (UsOnly)
中出 眞嗣 NAKADE, Shinji [JP/JP]; JP (UsOnly)
高岡 義和 TAKAOKA, Yoshikazu [JP/JP]; JP (UsOnly)
小野薬品工業株式会社 ONO PHARMACEUTICAL CO., LTD. [JP/JP]; 〒541-8526 大阪府 大阪市 中央区道修町2丁目1番5号 Osaka 1-5, Doshomachi 2-chome Chuo-ku, Osaka-shi Osaka 541-8526, JP (AllExceptUS)
Inventors:
田中 元之 TANAKA, Motoyuki; JP
中出 眞嗣 NAKADE, Shinji; JP
高岡 義和 TAKAOKA, Yoshikazu; JP
Agent:
大家 邦久 OHIE, Kunihisa; 〒103-0013 東京都 中央区 日本橋人形町2丁目14番6号 セルバ人形町6階 大家特許事務所 Tokyo Ohie Patent Office Selva-Ningyocho 6F 14-6, Nihonbashi-Ningyocho 2-chome Chuo-ku, Tokyo 103-0013, JP
Priority Data:
2003-42243119.12.2003JP
2004-10137830.03.2004JP
Title (EN) COMPOUNDS HAVING LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISM AND USES THEREOF
(FR) COMPOSES ANTAGONISTES DES RECEPTEURS A L'ACIDE LYSOPHOSPHATIDIQUE ET LEURS UTILISATIONS
(JA) リゾホスファチジン酸受容体拮抗作用を有する化合物およびその用途
Abstract:
(EN) Compounds represented by the general formula (I), salts of the same, solvates of both, or prodrugs thereof: (I) (wherein each symbol is as defined in the description). Since the compounds of the invention bind to LPA receptors (particularly EDG-2) and thus antagonize them, they are useful in the prevention and/or treatment of urologic diseases (such as symptoms due to prostatic hypertrophy or neurogenic bladder; tumor of spinal cord; intervertebral disk hernia; spinal canal stenosis; symptoms caused by diabetes; obstruction of lower urinary tract; inflammatory diseases of lower urinary tract; and polyuria), cancer-related diseases, proliferative diseases, inflammatory diseases, immunopathies, diseases due to secretion disturbance, brain-related diseases and/or chronic diseases.
(FR) La présente invention se rapporte à des composés représentés par la formule (I), dans laquelle chaque élément est tel que défini dans le descriptif de l'invention, à des sels de ces derniers, et à des solvates ou à des promédicaments desdits composés et sels. Etant donné qu'ils se lient aux récepteurs LPA (en particulier à EDG-2) et constituent donc des antagonistes de ces derniers, les composés selon l'invention sont utiles pour prévenir et/ou traiter des maladies urologiques (telles que les symptômes de l'hypertrophie prostatique ou de la vessie neurogène, les tumeurs de la moelle épinière, les hernies discales, la sténose du canal rachidien, les symptômes du diabète, l'obstruction du tractus urinaire inférieur, les maladies inflammatoires du tractus urinaire inférieur et la polyurie), des maladies associées au cancer, des maladies prolifératives, des maladies inflammatoires, des immunopathies, des maladies dues à des troubles sécrétoires, des maladies cérébrales et/ou des maladies chroniques.
(JA) not available
front page image
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)