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1. WO2005058790 - COMPOUNDS HAVING LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISM AND USES THEREOF

Publication Number WO/2005/058790
Publication Date 30.06.2005
International Application No. PCT/JP2004/019456
International Filing Date 17.12.2004
IPC
C07C 59/66 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
59Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O-metal, -CHO, keto, ether, groups, groups, or groups
40Unsaturated compounds
58containing ether groups, groups, groups, or groups
64containing six-membered aromatic rings
66the non-carboxylic part of the ether containing six-membered aromatic rings
C07C 69/734 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
69Esters of carboxylic acids; Esters of carbonic or haloformic acids
66Esters of carboxylic acids having esterified carboxyl groups bound to acyclic carbon atoms and having any of the groups OH, O-metal, -CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
73of unsaturated acids
734Ethers
C07C 69/92 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
69Esters of carboxylic acids; Esters of carbonic or haloformic acids
76Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a six-membered aromatic ring
84of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
92with etherified hydroxyl groups
CPC
A61P 1/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
10Laxatives
A61P 1/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
12Antidiarrhoeals
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
A61P 13/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
A61P 13/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
02of urine or of the urinary tract, e.g. urine acidifiers
Applicants
  • 小野薬品工業株式会社 ONO PHARMACEUTICAL CO., LTD. [JP]/[JP] (AllExceptUS)
  • 田中 元之 TANAKA, Motoyuki [JP]/[JP] (UsOnly)
  • 中出 眞嗣 NAKADE, Shinji [JP]/[JP] (UsOnly)
  • 高岡 義和 TAKAOKA, Yoshikazu [JP]/[JP] (UsOnly)
Inventors
  • 田中 元之 TANAKA, Motoyuki
  • 中出 眞嗣 NAKADE, Shinji
  • 高岡 義和 TAKAOKA, Yoshikazu
Agents
  • 大家 邦久 OHIE, Kunihisa
Priority Data
2003-42243119.12.2003JP
2004-10137830.03.2004JP
Publication Language Japanese (ja)
Filing Language Japanese (JA)
Designated States
Title
(EN) COMPOUNDS HAVING LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISM AND USES THEREOF
(FR) COMPOSES ANTAGONISTES DES RECEPTEURS A L'ACIDE LYSOPHOSPHATIDIQUE ET LEURS UTILISATIONS
(JA) リゾホスファチジン酸受容体拮抗作用を有する化合物およびその用途
Abstract
(EN) Compounds represented by the general formula (I), salts of the same, solvates of both, or prodrugs thereof: (I) (wherein each symbol is as defined in the description). Since the compounds of the invention bind to LPA receptors (particularly EDG-2) and thus antagonize them, they are useful in the prevention and/or treatment of urologic diseases (such as symptoms due to prostatic hypertrophy or neurogenic bladder; tumor of spinal cord; intervertebral disk hernia; spinal canal stenosis; symptoms caused by diabetes; obstruction of lower urinary tract; inflammatory diseases of lower urinary tract; and polyuria), cancer-related diseases, proliferative diseases, inflammatory diseases, immunopathies, diseases due to secretion disturbance, brain-related diseases and/or chronic diseases.
(FR) La présente invention se rapporte à des composés représentés par la formule (I), dans laquelle chaque élément est tel que défini dans le descriptif de l'invention, à des sels de ces derniers, et à des solvates ou à des promédicaments desdits composés et sels. Etant donné qu'ils se lient aux récepteurs LPA (en particulier à EDG-2) et constituent donc des antagonistes de ces derniers, les composés selon l'invention sont utiles pour prévenir et/ou traiter des maladies urologiques (telles que les symptômes de l'hypertrophie prostatique ou de la vessie neurogène, les tumeurs de la moelle épinière, les hernies discales, la sténose du canal rachidien, les symptômes du diabète, l'obstruction du tractus urinaire inférieur, les maladies inflammatoires du tractus urinaire inférieur et la polyurie), des maladies associées au cancer, des maladies prolifératives, des maladies inflammatoires, des immunopathies, des maladies dues à des troubles sécrétoires, des maladies cérébrales et/ou des maladies chroniques.
(JA) not available
Related patent documents
US2007149595This application is not viewable in PATENTSCOPE because the national phase entry has not been published yet or the national entry is issued from a country that does not share data with WIPO or there is a formatting issue or an unavailability of the application.
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