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1. (WO2005058299) PHENETHANOLAMINE DERIVATIVES FOR TREATMENT OF RESPIRATORY DISEASES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2005/058299 International Application No.: PCT/EP2004/013998
Publication Date: 30.06.2005 International Filing Date: 07.12.2004
IPC:
C07C 311/28 (2006.01) ,C07D 213/71 (2006.01) ,C07D 333/34 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
311
Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
22
Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
28
having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
213
Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02
having three double bonds between ring members or between ring members and non-ring members
04
having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
62
Oxygen or sulfur atoms
70
Sulfur atoms
71
to which a second hetero atom is attached
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
333
Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
02
not condensed with other rings
04
not substituted on the ring sulfur atom
26
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
30
Hetero atoms other than halogen
34
Sulfur atoms
Applicants:
GLAXO GROUP LIMITED [GB/GB]; Glaxo Wellcome House Berkeley Avenue Greenford Middlesex UB6 0NN, GB (AllExceptUS)
COE, Diane, Mary [GB/GB]; GB (UsOnly)
COX, Brian [GB/GB]; GB (UsOnly)
LOOKER, Brian, Edgar [GB/GB]; GB (UsOnly)
Inventors:
COE, Diane, Mary; GB
COX, Brian; GB
LOOKER, Brian, Edgar; GB
Agent:
FLORENCE, Julia, Anne; GlaxoSmithKline Corporate Intellectual Property CN925.1 980 Great West Road Brentford, Middlesex TW8 9GS, GB
Priority Data:
0328490.809.12.2003GB
Title (EN) PHENETHANOLAMINE DERIVATIVES FOR TREATMENT OF RESPIRATORY DISEASES
(FR) DERIVES DE PHENETHANOLAMINE DESTINES AU TRAITEMENT DE MALADIES RESPIRATOIRES
Abstract:
(EN) Compounds of formula (I): Wherein: R1 is-XSO2NR6R7; wherein X is -(CH2)p - or C2-6 alkenylene; p is an integer from 0 to 6; Ar2 is a mono or bicyclic heteroaryl or a bicyclic aryl group; and salts, solvates, and physiologically functional derivatives thereof, useful for the prophylaxis or treatment of a clinical condition for which a selective &bgr;2-adrenoreceptor agonist is indicated, for example asthma or chronic obstructive pulmonary disease (COPD).
(FR) L'invention concerne des composés de formule (I), dans laquelle R1 est -XSO2NR6R7; X est -(CH2)p - ou alcénylène C2-6; p est un entier compris entre 0 et 6; Ar2 est un hétéroaryle mono ou bicyclique ou un groupe aryle bicyclique; et des sels, solvates et dérivés physiologiquement fonctionnels desdits composés, utiles pour la prophylaxie ou le traitement d'un état clinique pour lequel un agoniste du récepteur bêta2-adrénergique est indiqué, tel que l'asthme ou la bronchopneumopathie chronique obstructive (BPCO).
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)